Table 3.

IL8 and IL8RB genotype frequencies among study participants

Subcohort*
GCC
ESCC
WTHtHvWTHtHvWTHtHv
IL8 −251 T/T T/A A/A147 (34.3)207 (48.3)75 (17.5)26 (29.6)39 (44.3)23 (26.1)48 (37.2)55 (42.6)26 (20.2)
IL8 +396 T/T G/T G/G152 (37.8)181 (45.0)69 (17.2)29 (33.7)33 (38.4)24 (27.9)49 (39.5)50 (40.3)25 (20.2)
IL8 +781 C/C C/T T/T167 (41.1)177 (43.6)62 (15.3)28 (32.9)41 (48.2)16 (18.8)53 (42.1)51 (40.5)22 (17.5)
IL8RB +785 T/T T/C C/C346 (82.6)71 (17.0)2 (0.5)71 (79.8)17 (19.1)1 (1.1)108 (83.7)21 (16.3)0 (0.0)
IL8RB +1208 C/C C/T T/T202 (48.7)154 (37.1)59 (14.2)56 (62.9)22 (24.7)11 (12.4)61 (48.4)45 (35.7)20 (15.9)
IL8RB +1440 G/G G/A A/A241 (57.8)149 (35.7)27 (6.5)45 (51.7)36 (41.4)6 (6.9)77 (61.6)39 (31.2)9 (7.2)
  • NOTE: Genotype frequencies are presented as n (%). Abbreviations: WT, wild-type (the most frequent allele in our population); Ht, heterozygous; Hv, homozygous variant.

  • * The subcohort was tested by χ2 to determine if the population meets the assumption of Hardy-Weinberg equilibrium for each: IL8 −251, P = 0.89; IL8 +396, P = 0.23; IL8 +781, P = 0.19; IL8RB +785, P = 0.42; IL8RB +1208, P = 0.001; IL8RB +1440, P = 0.54.