Table 4.

Relative risk of colorectal cancer by genotype at subsites of colorectum

GenotypeCaecum/ascendens
Transversum/descendens
Sigmoideum
Rectum
Cases/controlOR (95% CI)Cases/controlOR (95% CI)Cases/controlOR (95% CI)Cases/control
OR (95% CI)
MTHFR 677
    CC210/2091145/1401301/3091411/3961
    CT150/1570.95 (0.71-1.29)135/1271.04 (0.73-1.48)245/2331.10 (0.87-1.41)341/3450.96 (0.78-1.18)
    TT38/361.09 (0.62-1.91)21/380.57 (0.32-1.01)46/600.80 (0.52-1.23)52/730.69 (0.47-1.02)
MTR 2756
    AA262/2641191/1831403/3831544/5281
    AG119/1270.95 (0.70-1.29)93/1070.85 (0.61-1.18)177/1840.92 (0.72-1.19)236/2510.92 (0.74-1.14)
    GG16/111.47 (0.66-3.30)17/151.06 (0.52-2.15)10/350.26 (0.12-0.54)21/330.64 (0.37-1.12)
  • NOTE: Analyzed by conditional logistic regression stratified by case-control sets.