Table 3.

Relative risk of colorectal cancer by genotype at different strata of tHcy*

GenotypeSex-specific tertiles of tHcy
Overall
Tertile 1
Tertile 2
Tertile 3
Cases/controlOR (95% CI)Cases/controlOR (95% CI)Cases/controlOR (95% CI)Cases/controlOR (95% CI)
MTHFR 677
    CC466/4861158/1921169/1561.37 (1.00-1.87)139/1381.32 (0.95-1.84)
    CT369/3591.06 (0.87-1.29)106/1181.09 (0.77-1.53)124/1251.25 (0.90-1.75)139/1161.51 (1.08-2.12)
    TT73/751.01 (0.71-1.44)16/191.03 (0.51-2.10)19/161.51 (0.75-3.06)38/401.21 (0.73-1.99)
MTR 2756
    AA611/5991185/2151205/1841.34 (1.01-1.79)221/2001.37 (1.03-1.83)
    AG271/2850.95 (0.78-1.17)90/1011.06 (0.75-1.50)96/981.22 (0.86-1.74)85/861.23 (0.85-1.79)
    GG27/370.71 (0.43-1.19)6/130.54 (0.20-1.47)12/150.94 (0.43-2.08)9/91.24 (0.48-3.23)
  • NOTE: Analyzed by unconditional logistic regression with adjustment for matching variables.

  • * tHcy measurements available only for 909 cases and 921 controls.