Table 2.

Relative risk of colorectal cancer by MTHFR 677C → and MTR 2756A → G genotypes and according to gender and age at diagnosis

All subjects
Men
Women
CasesControlsOR (95% CI)CasesControlsOR (95% CI)CasesControlsOR (95% CI)
MTHFR genotype
    CC1,1031,092171069513933971
    CT8998861.01 (0.89-1.15)5605620.98 (0.84-1.15)3393241.06 (0.86-1.30)
    TT1572120.73 (0.58-0.92)1021330.76 (0.57-1.01)55790.69 (0.46-1.02)
Age <65 y
    CC706714143043512762791
    CT6025761.07 (0.92-1.25)3543401.07 (0.87-1.31)2482361.07 (0.84-1.37)
    TT831270.66 (0.48-0.90)56810.70 (0.48-1.02)27460.58 (0.33-1.00)
Age ≥65 y
    CC397376128026011171161
    CT2973100.91 (0.73-1.13)2062220.85 (0.66-1.11)91881.03 (0.70-1.53)
    TT74850.83 (0.58-1.18)46520.83 (0.54-1.28)28330.83 (0.45-1.52)
MTR genotype
    AA1,4571,402193789515105041
    AG6476930.90 (0.79-1.02)3964360.86 (0.73-1.02)2452540.96 (0.78-1.18)
    GG64970.65 (0.47-0.90)35570.58 (0.38-0.89)29400.73 (0.44-1.19)
Age <65 y
    AA933918158055813533601
    AG4044370.91 (0.78-1.07)2312630.85 (0.68-1.05)1731741.01 (0.78-1.29)
    GG49610.79 (0.54-1.17)26340.72 (0.43-1.23)23270.88 (0.49-1.57)
Age ≥65 y
    AA514481135733711571441
    AG2372530.87 (0.70-1.09)1651730.88 (0.67-1.15)72800.86 (0.58-1.26)
    GG15360.40 (0.22-0.73)9230.37 (0.17-0.81)6130.44 (0.17-1.17)
  • NOTE: Analyzed by conditional logistic regression stratified by case-control sets.