Relative risk of colorectal cancer by MTHFR 677C → and MTR 2756A → G genotypes and according to gender and age at diagnosis
| All subjects | Men | Women | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR (95% CI) | Cases | Controls | OR (95% CI) | Cases | Controls | OR (95% CI) | ||||||||||
| MTHFR genotype | ||||||||||||||||||
| CC | 1,103 | 1,092 | 1 | 710 | 695 | 1 | 393 | 397 | 1 | |||||||||
| CT | 899 | 886 | 1.01 (0.89-1.15) | 560 | 562 | 0.98 (0.84-1.15) | 339 | 324 | 1.06 (0.86-1.30) | |||||||||
| TT | 157 | 212 | 0.73 (0.58-0.92) | 102 | 133 | 0.76 (0.57-1.01) | 55 | 79 | 0.69 (0.46-1.02) | |||||||||
| Age <65 y | ||||||||||||||||||
| CC | 706 | 714 | 1 | 430 | 435 | 1 | 276 | 279 | 1 | |||||||||
| CT | 602 | 576 | 1.07 (0.92-1.25) | 354 | 340 | 1.07 (0.87-1.31) | 248 | 236 | 1.07 (0.84-1.37) | |||||||||
| TT | 83 | 127 | 0.66 (0.48-0.90) | 56 | 81 | 0.70 (0.48-1.02) | 27 | 46 | 0.58 (0.33-1.00) | |||||||||
| Age ≥65 y | ||||||||||||||||||
| CC | 397 | 376 | 1 | 280 | 260 | 1 | 117 | 116 | 1 | |||||||||
| CT | 297 | 310 | 0.91 (0.73-1.13) | 206 | 222 | 0.85 (0.66-1.11) | 91 | 88 | 1.03 (0.70-1.53) | |||||||||
| TT | 74 | 85 | 0.83 (0.58-1.18) | 46 | 52 | 0.83 (0.54-1.28) | 28 | 33 | 0.83 (0.45-1.52) | |||||||||
| MTR genotype | ||||||||||||||||||
| AA | 1,457 | 1,402 | 1 | 937 | 895 | 1 | 510 | 504 | 1 | |||||||||
| AG | 647 | 693 | 0.90 (0.79-1.02) | 396 | 436 | 0.86 (0.73-1.02) | 245 | 254 | 0.96 (0.78-1.18) | |||||||||
| GG | 64 | 97 | 0.65 (0.47-0.90) | 35 | 57 | 0.58 (0.38-0.89) | 29 | 40 | 0.73 (0.44-1.19) | |||||||||
| Age <65 y | ||||||||||||||||||
| AA | 933 | 918 | 1 | 580 | 558 | 1 | 353 | 360 | 1 | |||||||||
| AG | 404 | 437 | 0.91 (0.78-1.07) | 231 | 263 | 0.85 (0.68-1.05) | 173 | 174 | 1.01 (0.78-1.29) | |||||||||
| GG | 49 | 61 | 0.79 (0.54-1.17) | 26 | 34 | 0.72 (0.43-1.23) | 23 | 27 | 0.88 (0.49-1.57) | |||||||||
| Age ≥65 y | ||||||||||||||||||
| AA | 514 | 481 | 1 | 357 | 337 | 1 | 157 | 144 | 1 | |||||||||
| AG | 237 | 253 | 0.87 (0.70-1.09) | 165 | 173 | 0.88 (0.67-1.15) | 72 | 80 | 0.86 (0.58-1.26) | |||||||||
| GG | 15 | 36 | 0.40 (0.22-0.73) | 9 | 23 | 0.37 (0.17-0.81) | 6 | 13 | 0.44 (0.17-1.17) | |||||||||
NOTE: Analyzed by conditional logistic regression stratified by case-control sets.