Table 3.

Association between progesterone receptor polymorphism and risk of invasive and borderline epithelial ovarian tumors by histologic type and study

GGAGAAAG/AA (%)OR*(95% CI)
North Carolina study
Controls44558159 (11.7)1.00 (reference)
Serous24426026 (9.6)0.81 (0.50-1.32)
Mucinous44505 (10.2)0.80 (0.30-2.14)
Endometrioid53303 (5.4)0.43 (0.13-1.40)
Clear cell23000 (0.0)
Endometrioid/clear cell76303 (3.8)0.30 (0.09-0.97)
Mixed1000 (0.0)
Other35314 (10.3)0.86 (0.29-2.51)
Australian study
Controls26630232 (10.7)1.00 (reference)
Serous28531233 (10.4)0.89 (0.52-1.52)
Mucinous55606 (9.8)0.91 (0.36-2.27)
Endometrioid59314 (6.3)0.51 (0.17-1.53)
Clear cell29303 (9.4)0.83 (0.24-2.92)
Endometrioid/clear cell88617 (7.4)0.60 (0.25-1.44)
Mixed32314 (11.1)1.01 (0.32-3.17)
Other23202 (8.0)0.73 (0.15-3.44)
  • * ORs are according to genotype (AG/GG) compared with the reference group genotype (GG) and are adjusted for age and corresponding study.

  • Sample size too small to calculate.