Table 1.

Group means and Ps for quantitative biomarkers derived from histochemical staining and image analysis

ParameterGroup
P
Nonexposed (n = 32)Sun damaged (n = 102)AK (n = 102)Sun damaged versus nonexposedAK versus nonexposedAK versus sun damaged
Absorbance66.9 ± 12.6671.8 ± 18.9086.8 ± 27.100.5724<0.0001<0.0001
Nuclear shape15.3 ± 0.9715.5 ± 0.8917.0 ± 1.680.5724<0.0001<0.0001
Nuclear size43.6 ± 6.1447.8 ± 10.6360.8 ± 15.490.3767<0.0001<0.0001
Variability of absorbance19.7 ± 8.5422.4 ± 7.7033.3 ± 11.360.3487<0.0001<0.0001
Variability of nuclear shape3.2 ± 2.493.2 ± 1.745.8 ± 3.470.6511<0.0001<0.0001
Variability of nuclear size9.7 ± 3.1810.8 ± 4.0917.0 ± 5.520.5045<0.0001<0.0001
AgNOr no. per nucleus1.2 ± 0.351.0 ± 0.581.5 ± 0.430.16220.0263<0.0001
Total AgNOr area per nucleus2.8 ± 1.382.64 ± 2.135.6 ± 2.890.5724<0.0001<0.0001
% Ki6710.5 ± 4.4316.7 ± 7.6027.7 ± 9.860.0002<0.0001<0.0001
% p537.8 ± 8.7419.7 ± 11.8235.5 ± 10.76<0.0001<0.0001<0.0001