Table 3.

Breast cancer ORs (95% CIs) by MTHFR C677T or A1298C genotype and ethnicity

Ethnicityn*ORnOR (95% CI)nOR (95% CI)P
C677T
CCCTTT
Japanese American135/1401.00140/1960.75 (0.53-1.03)43/740.60 (0.39-0.94)0.02
White131/1781.00151/1761.11 (0.81-1.54)38/610.80 (0.50-1.29)0.65
African American196/4901.0047/1400.83 (0.57-1.20)3/90.86 (0.23-3.23)0.34
Latino70/2181.00117/3191.20 (0.85-1.70)49/1271.19 (0.78-1.83)0.36
Hawaiian41/1851.0024/891.25 (0.71-2.21)4/121.40 (0.42-4.69)0.38
A1298C
AAACCC
Japanese American224/2711.0083/1260.81 (0.58-1.13)11/131.13 (0.49-2.58)0.44
White160/2111.00118/1660.91 (0.66-1.25)42/381.39 (0.85-2.28)0.48
African American171/4331.0068/1870.92 (0.67-1.29)7/190.96 (0.40-2.34)0.68
Latino146/4231.0077/2121.07 (0.78-1.48)13/291.24 (0.63-2.47)0.50
Hawaiian40/1551.0025/1100.85 (0.48-1.49)4/210.73 (0.23-2.26)0.46
  • NOTE: Adjusted for age at blood draw.

  • * No. cases/no. controls.

  • P value for gene dosage term assigned 1, 2, and 3 for 0, 1, and 2 variant alleles, respectively.