Table 2.

STK15 allele and genotype frequencies, unadjusted and adjusted ORs for breast cancer, Shanghai Breast Cancer Study, 1996-1998

STK15Cases, n (%)Controls, n (%)OR* (95% CI)OR (95% CI)
Genotype frequencies (%)
Phe31Ile
    Phe/Phe121 (11.0)149 (12.6)1.01.0
    Phe/Ile491 (44.6)503 (42.4)1.2 (0.9-1.6)1.3 (1.0-1.7)
    Ile/Ile490 (44.5)534 (45.0)1.1 (0.9-1.5)1.2 (0.9-1.6)
        P for trend0.730.66
Val57Ile
    Val/Val805 (73.0)908 (76.1)1.01.0
    Val/Ile281 (25.5)263 (22.0)1.2 (1.0-1.5)1.2 (1.0-1.5)
    Ile/Ile16 (1.4)17 (1.6)0.8 (0.4-1.6)0.8 (0.4-1.6)
        P for trend0.190.20
Combined
Codon 31Codon 57
Phe/PheVal/Val45 (4.2)66 (5.7)1.01.0
Val/Ile or Ile/Ile72 (6.7)76 (6.6)1.2 (0.8-1.9)1.2 (0.7-1.9)
    Val/Ile56 (5.2)56 (4.8)
    Ile/Ile16 (1.5)20 (1.7)
Phe/IleVal/Val261 (24.3)290 (25.1)1.1 (0.8-1.6)1.2 (0.8-1.7)
Val/Ile or Ile/Ile215 (20.1)198 (17.1)1.4 (1.0-2.0)1.4 (1.0-2.1)
    Val/Ile215 (20.1)196 (16.9)
    Ile/Ile0 (0.0)2 (0.2)
Ile/IleVal/Val476 (44.4)525 (454)1.1 (0.8-1.6)1.2 (0.8-1.7)
Val/Ile or Ile/Ile3 (0.3)2 (0.2)1.9 (0.3-11.4)1.2 (0.2-9.2)
    Val/Ile3 (0.3)2 (0.2)
    Ile/Ile0 (0.0)0 (0.0)
  • NOTE: The frequencies of the Ile31 allele were 67( in cases and 66% in controls (P = 0.71), and frequencies of the Ile57 allele were 14( in cases and 13% in controls (P = 0.19).

  • * Adjusted for age only.

  • Adjusted for age, personal history of fibroadenoma, WHR, age at first live birth, age at menarche, physical activity, and menopausal status.