Table 5.

Combined genotypes of ERCC2_6540_G>A (Asp312Asn) and ERCC2_18880_A>C (Lys751Gln)

Genotypes
Cases, n (%)Controls, n (%)ORadj* (95% CI)
ERCC2_6540ERCC2_18880
GGAA187 (34)216 (36)1.00 (reference)
GGAC113 (21)50 (8)2.61 (1.77-3.85)
GGCC34 (6)10 (2)3.69 (1.76-7.74)
GAAA23 (4)34 (6)0.82 (0.46-1.44)
GAAC116 (21)197 (32)0.70 (0.52-0.95)
GACC31 (6)22 (4)1.62 (0.90-2.91)
AAAA3 (1)5 (1)0.75 (0.17-3.23)
AAAC15 (3)27 (4)0.67 (0.35-1.31)
AACC29 (5)47 (8)0.70 (0.42-1.16)
  • * ORadj conditional on age in 5-year groups, adjusted for smoking, history of breast cancer in mother or sisters, HRT, and parity.