Table 4.

ERCC2_6540_G>A (Asp312Asn) genotypes and potential breast cancer risk factors

AA
GA
GG
Cases, n (%)Controls, n (%)OR (95% CI)Cases, n (%)Controls, n (%)OR (95% CI)Cases, n (%)Controls, n (%)OR (95% CI)
Age (y)
    <5015 (12)19 (13)1.00* (reference)29 (23)65 (46)0.59* (0.3-1.4)82 (65)57 (40)2.02* (0.9-4.5)
    ≥5032 (7)60 (13)1.00* (reference)144 (33)190 (41)1.44* (0.9-2.3)259 (60)219 (47)2.17* (1.4-3.5)
Menopausal status
    Premenopausal15 (12)17 (12)1.00* (reference)34 (27)65 (46)0.60* (0.3-1.4)81 (62)58 (41)1.56* (0.7-3.4)
    Postmenopausal32 (8)62 (13)1.00* (reference)137 (32)185 (40)1.4* (0.9-2.3)255 (60)217 (47)2.20* (1.4-3.5)
Smoking status
    Never27 (8)42 (12)1.00 (reference)105 (32)133 (39)1.20 (0.7-2.1)195 (60)163 (48)1.77 (1.0-3.0)
    Ever20 (9)37 (14)1.00 (reference)68 (29)122 (45)1.01 (0.5-1.9)146 (62)113 (42)2.25 (1.2-4.1)
  • * ORadj conditional on age in 5-year groups, adjusted for smoking, history of breast cancer in mother or sisters, HRT, and parity.

  • ORadj conditional on age in 5-year groups, adjusted for history of breast cancer in mother or sisters, HRT, and parity.