Table 3.

Association of ERCC2 polymorphisms with breast cancer risk

GenotypeCases, n (%)Controls, n (%)ORadj* (95% CI)
ERCC2_6540_G>A (Asp312Asn)
    AA47 (8)79 (13)1.00 (reference)
    GA173 (31)255 (42)1.15 (0.76-1.74)
    GG347 (61)276 (45)2.06 (1.39-3.07)
ERCC2_18880_A>C (Lys751Gln)
    AA224 (38)264 (41)1.00 (reference)
    AC265 (45)292 (45)1.09 (0.85-1.39)
    CC97 (17)87 (14)1.32 (0.94-1.86)
  • * ORadj conditional on age in 5-year groups, adjusted for smoking, history of breast cancer in mother or sisters, HRT, and parity.