Table 3

Association between MTR D919G genotype, polymorphisms in folate metabolism, and risk of adenomatous polyps

WomenMen
DDDGGGP, inter- actiondDDDGGGP, inter- actiond
naORb,c (95% CI)naORb (95% CI)naORb (95% CI)naORb (95% CI)naORb (95% CI)naORb (95% CI)
Unstratified106/2341.0 (reference)60/981.4 (0.9–2.1)11/111.7 (0.7–4.3)201/1431.0 (reference)96/741.0 (0.6–1.4)11/61.6 (0.5–4.6)
MTHFR C677T
 CC52/1011.0 (reference)32/511.3 (0.7–2.4)9/62.1 (0.7–6.8)90/661.0 (reference)47/310.9 (0.5–1.6)6/41.3 (0.3–5.2)
 CT37/1030.7 (0.4–1.1)19/351.0 (0.5–1.9)2/50.6 (0.1–3.6)94/571.1 (0.7–1.8)39/370.9 (0.5–1.6)5/14.1 (0.4–39.8)
 TT16/291.1 (0.5–2.4)8/121.1 (0.4–3)0/0NA0.8015/190.4 (0.2–1.0)10/61.4 (0.5–4.4)0/1NA0.21
TSERe
 3 rpt/3 rpt30/611.0 (reference)16/231.3 (0.6–3.1)3/22.3 (0.3–18.1)62/411.0 (reference)32/161.6 (0.8–3.5)2/11.5 (0.1–21.3)
 3 rpt/2 rpt50/1200.8 (0.5–1.5)32/561.1 (0.5–2.1)7/61.7 (0.5–6.1)93/730.9 (0.5–1.5)43/410.8 (0.4–1.5)9/24.0 (0.8–21.0)
 2 rpt/2 rpt24/530.9 (0.5–1.9)11/171.8 (0.7–4.8)1/30.7 (0.1–7.4)0.8444/281.1 (0.5–2.1)21/150.7 (0.3–1.6)0/3NA0.33
TS 3′UTRf
 wt/wt41/1221.0 (reference)22/471.6 (0.8–3.1)7/45.0 (1.3–19.5)97/771.0 (reference)49/261.5 (0.8–2.7)5/60.8 (0.2–3.0)
 wt/del51/921.7 (1.0–2.8)36/392.6 (1.4–4.9)4/61.1 (0.3–4.4)78/521.2 (0.7–1.9)40/400.9 (0.5–1.5)3/0NA
 del/del14/202.8 (1.2–6.5)2/120.4 (0.1–2.2)0/1NA0.00725/141.6 (0.8–3.4)7/80.8 (0.3–2.5)3/0NA0.15
  • a Number of cases/number of controls; numbers differ slightly for some polymorphisms.

  • b Adjusted for age, hormone therapy (women only; ever/never), body mass index, pack-years of smoking, regular use of nonsteroidal anti-inflammatory drugs (≥1/week), daily energy intake, dietary fiber, percentage of daily kilocalories from fat, and daily dietary intakes of folate, vitamin B12, vitamin B6, methionine, and alcohol.

  • c OR, odds ratio; CI, confidence interval; NA, not calculated; TSER, TS enhancer region; rpt, repeats; UTR, untranslated region; wt, wild type; del, deletion.

  • d Significance of gene–gene interactions determined by likelihood ratio testing of models with and without a multiplicative interaction term.

  • e TS enhancer region, 28-bp repeat polymorphism.

  • f TS 3′ untranslated region, 1494del6.