Table 1

Characteristics of study participants

Women (n = 563)aMen (n = 559)
Cases (n = 190)Controls (n = 373)PbCases (n = 323)Controls (n = 236)Pb
MTR D919G genotype, n (%)
 DD114 (60)256 (69)214 (66)152 (64)
 DG64 (34)105 (28)97 (30)78 (33)
 GG12 (6)12 (3)0.2512 (4)6 (3)0.59
Age, n (%)
 <40 years8 (4)52 (14)14 (4)28 (12)
 40–49 years32 (17)91 (24)47 (15)68 (29)
 50–59 years57 (30)115 (31)107 (33)77 (33)
 60–69 years69 (36)91 (24)120 (37)47 (20)
 70+ years24 (13)24 (6)<0.00135 (11)16 (7)<0.001
Other characteristics,c mean (range)
 Folate intake, μg/day404 (70–1623)411 (84–1396)0.75396 (79–1952)423 (101–1457)0.16
 Vitamin B12 intake, μg/day7.9 (0.4–62.5)8.6 (0.4–102.5)0.319.5 (1.1–221.8)10.6 (0.9–105.3)0.29
 Vitamin B6 intake, mg/day5.9 (0.8–102.2)7.8 (0.7–103.7)0.244.2 (0.7–106.1)5.1 (0.6–101.8)0.39
 Methionine intake, g/day1.8 (0.4–5.6)1.9 (0.3–5.0)0.122.2 (0.5–5.6)2.1 (0.7–6.3)0.44
 Alcohol intake, g/day4.9 (0.0–91.7)3.6 (0.0–68.0)0.1213.5 (0.0–118.7)10.9 (0.0–96.3)0.11
 Pack-years of smoking12.5 (0.0–130.5)10.1 (0.0–135.0)0.1524.2 (0.0–138.8)16.9 (0.0–157.3)<0.001
 Body mass index, kg/m226.3 (17.3–44.9)26.8 (16.3–46.2)0.3627.8 (14.4–44.6)27.0 (18.6–40.1)0.02
  • a Controls were 61% female; cases were 63% male (P < 0.001).

  • b Significance of case-control differences; χ2 test for categorical traits and t test for continuous traits.

  • c Dietary intakes were available from 554 women and 547 men and included intakes from dietary supplements.