Table 1.

Summary of family characteristics

FamilyBRCA1 resultsBRCA2 resultsAge of breast cancer diagnosis probandMean age breast cancer diagnosis familyTotal breast cancersTotal ovarian cancersOther cancers in relatives
1VUSDel40413*0
2NegDel373620PGF prostate cancer
3NegNeg4149.520
4NegNeg454020
5VUSVUS343410F lung cancer
6VUSNeg393910MGF throat cancer
7DelNeg3034.340
8NegNeg6260.540
9NegNeg404010
10DelNeg292910F leukemia
  • NOTE: VUS, variants of uncertain significance; F, father; PGF, paternal grandfather; MGF, maternal grandfather.

  • * Includes bilateral breast cancer in the proband.

  • Does not include the diagnosis of breast cancer in the proband's maternal grandmother, because the mutation was determined to be paternally inherited.