Table 4.

Serum micronutrient levels in relation to risk of gastric cancer, Shanghai Cohort Study, 1986-1998

MicronutrientsQuartile*
P for trend
FirstSecondThirdFourth
α-Carotene
    OR (95% CI)1.000.63 (0.22-1.83)0.54 (0.19-1.55)0.38 (0.13-1.11)0.04
    Adjusted OR (95% CI)1.000.55 (0.19-1.59)0.52 (0.18-1.50)0.39 (0.13-1.14)0.09
β-Carotene
    OR (95% CI)1.000.74 (0.47-1.16)0.58 (0.36-0.95)0.54 (0.32-0.89)0.01
    Adjusted OR (95% CI)1.000.81 (0.51-1.29)0.64 (0.40-1.05)0.62 (0.37-1.06)0.05
β-Cryptoxanthin
    OR (95% CI)1.000.84 (0.51-1.39)0.70 (0.41-1.21)0.80 (0.47-1.38)0.41
    Adjusted OR (95% CI)1.000.90 (0.53-1.52)0.74 (0.43-1.30)0.90 (0.51-1.58)0.66
Lycopene
    OR (95% CI)1.000.85 (0.51-1.41)0.73 (0.43-1.25)0.55 (0.30-1.00)0.05
    Adjusted OR (95% CI)1.000.89 (0.53-1.49)0.80 (0.46-1.37)0.63 (0.34-1.15)0.13
Lutein/zeaxanthin
    OR (95% CI)1.001.19 (0.75-1.89)0.96 (0.59-1.58)1.10 (0.67-1.81)0.91
    Adjusted OR (95% CI)1.001.20 (0.75-1.92)0.96 (0.57-1.60)1.12 (0.67-1.86)0.88
Retinol
    OR (95% CI)1.000.97 (0.62-1.52)0.85 (0.53-1.36)0.88 (0.54-1.44)0.51
    Adjusted OR (95% CI)1.000.97 (0.62-1.53)0.83 (0.51-1.34)0.86 (0.52-1.43)0.45
Vitamin C
    OR (95% CI)1.001.02 (0.65-1.58)0.82 (0.50-1.33)0.72 (0.44-1.19)0.14
    Adjusted OR (95% CI)1.001.19 (0.76-1.88)0.97 (0.58-1.60)0.92 (0.55-1.55)0.57
α-Tocopherol
    OR (95% CI)1.000.94 (0.58-1.52)1.11 (0.68-1.83)1.26 (0.76-2.09)0.28
    Adjusted OR (95% CI)1.000.96 (0.59-1.58)1.10 (0.66-1.81)1.23 (0.74-2.06)0.36
γ-Tocopherol
    OR (95% CI)1.001.11 (0.69-1.77)1.01 (0.62-1.65)1.18 (0.70-1.97)0.65
    Adjusted OR (95% CI)1.001.14 (0.70-1.83)1.10 (0.67-1.81)1.19 (0.70-2.00)0.57
  • * See Appendix 1 for quartile cut points.

  • ORs were derived from conditional logistic regression models that retained a matched set consisting of three control subjects individually matched to the index case by age, month and year of biospecimen collection, and neighborhood of residence at recruitment.

  • Further adjusted for cigarette smoking (never or ever), alcohol consumption (<3 or ≥3 drinks per day), positivity of urinary epigallocatechin (no or yes), and seropositivity of H. pylori antibodies (no or yes).