Contribution of selected factors on the magnitude of the ORsa for the association between the p53 codon 72 polymorphism and cervical neoplasia: results from meta-regression
| Study design characteristic | Contrast | Ratio of odds ratios (95% confidence interval) | |||
|---|---|---|---|---|---|
| ICC (n = 24) | SCC (n = 22) | HSIL (n = 22) | LSIL (n = 18) | ||
| Year of publication | 2000s vs. 1990s | 0.89 (0.64–1.24) | 1.40 (0.85–2.30) | 1.13 (0.86–1.49) | 1.23 (0.86–1.78) |
| Geographical region of study | Europe vs. Other regions | 1.00 (0.68–1.45) | 0.94 (0.56–1.61) | 1.09 (0.84–1.41) | 0.86 (0.59–1.26) |
| Control group in Hardy-Weinberg equilibrium | Not in equilibrium vs. in equilibrium | 1.46 (1.05–2.02) | 2.28 (1.34–3.86) | 1.23 (0.96–1.57) | 1.05 (0.61–1.80) |
| Sampling of control group | Convenience vs. risk-based | 1.26 (0.89–1.77) | 1.43 (0.89–2.30) | 0.94 (0.72–1.23) | 1.11 (0.75–1.64) |
| Control for ethnicity/race | Uncontrolled vs. controlled | 0.91 (0.63–1.32) | 0.78 (0.46–1.31) | 0.90 (0.69–1.17) | 0.76 (0.54–1.09) |
| Genotyping method utilized | Allele-specific PCR vs. other | 1.35 (0.98–1.86) | 1.06 (0.63–1.76) | 0.99 (0.76–1.28) | 0.99 (0.68–1.42) |
| One method vs. > one method | 1.15 (0.67–1.98) | 1.01 (0.49–2.07) | 1.37 (0.84–2.25) | 1.07 (0.62–1.84) | |
| Restriction of case group | High-risk HPV+ vs. unrestricted | 0.78 (0.53–1.14) | 1.99 (1.24–3.19) | 1.03 (0.79–1.35) | 0.90 (0.58–1.41) |
| DNA source used for case group | Cervical tissue vs. blood | 1.15 (0.82–1.61) | 0.92 (0.51–1.65) | 0.99 (0.76–1.31) | 1.33 (0.82–2.16) |
| Archival vs. fresh tissue | 1.47 (0.86–2.54) | 0.98 (0.46–2.10) | 1.35 (1.02–1.80) | 1.40 (0.95–2.09) | |
| DNA source used for controls | Archival vs. fresh tissue | 1.29 (0.63–2.64) | 1.25 (0.62–2.51) | 1.02 (0.73–1.45) | 0.89 (0.57–1.39) |
a OR, odds ratio; ICC, invasive cervical cancer; SCC, squamous cell carcinoma; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion.