Table 1

Characteristics of studies examining the p53 codon 72 polymorphism and cervical neoplasia

First author yearGeographic locationStudy sizeDNA sourceGenotyping methodaControl for ethnicitybControl samplingCase restrictionsaHWE pc
GroupaNCasesControls
Storey 1998United KingdomNormal41Cervix freshBloodASPRestrictionConvenienceNone0.05
Cancer30
Strickler 1998JamaicaNormal30BloodBloodRFLPRestrictionRisk-basedNone0.79
Cancer28
Rosenthal 1998United KingdomNormal246Cervix archivalBloodASPRestrictionConvenienceNone0.12
Cancer50
Minaguchi 1998JapanNormal110Cervix archivalBloodASPRestrictionConvenienceNone0.69
Cancer103
Lanham 1998United KingdomNormal250Cervix freshBloodASPNoneRisk-based (hospital)None0.97
SIL265
Cancer38
Hayes 1998NetherlandsNormal158BloodBloodASPRestrictionConvenienceNone0.95
SILd147
Cancerd25
Helland 1998SwedenNormal225BloodBloodRFLPN.S.Risk-based (population)HPV16/18+0.50
SIL91
Cancer77
Josefsson 1998SwedenNormal626Cervix archivalCervix archivalRFLPNot clearRisk-based (population)None0.06
SIL488
Cancer63
Hildesheim 1998Costa RicaNormal123BloodBloodSSCPN.S.Risk-based (nested)None0.11
SIL198
Cancer49
Hildesheim 1998United StatesNormal217Cervix freshCervix freshSSCPN.S.Risk-based (nested)None0.51
SIL208
Hildesheim 1998United StatesNormal245Cervix freshCervix freshSSCPN.S.Risk-basedNone0.86
SIL47
Cancer123
Klaes 1999GermanyNormal151Cervix freshCervix freshRFLPRestrictionRisk-basedNone0.94
Cancer87
Sonoda 1999United StatesNormal100Cervix archivalCervix archivalDSNoneRisk-based (hospital)None0.22
Cancer105
Szarka 1999HungaryNormal87Cervix freshBloodASPRestrictionConvenienceSIL cases high-risk HPV+0.82
SIL86
Cancer82
Zehbe 1999SwedenNormale626Cervix archivalCervix archivalSSCPN.S.Convenience (previously published)HPV16+0.06
SIL54
Cancer30
Zehbe 1999ItalyNormal40Cervix archivalBloodSSCPRestrictionConvenience (babies)HPV16+0.21
SIL24
Cancer28
Ngan 1999Hong KongNormal68Cervix freshCervix freshASPRestrictionConvenienceNone0.01
Cancer102
Bertorelle 1999ItalyNormalf100Cervix freshCervix freshASPRestrictionRisk-based (nested)None0.31
SIL104
Wang 1999TaiwanNormal56Cervix freshCervix freshRFLP; DSRestrictionConvenienceNone0.19
Cancer58
Yamashita 1999JapanNormal252Cervix archivalCervix archivalRFLPRestrictionRisk-basedNone0.07
SIL88
Cancer76
Giannoudis 1999United KingdomNormal30Cervix archivalCervix archivalASP; RFLPN.S.ConvenienceNone0.52
SIL236
Cancer43
Brady 1999United KingdomNormal74BloodBloodASPN.S.ConvenienceHPV16+0.26
Cancer85
Tachezy 1999Czech RepublicNormal74Cervix freshCervix freshASPRestrictionRisk-basedNone0.12
Cancer71
Dybikowska 2000PolandNormal52Cervix freshCervix freshASPRestrictionRisk-basedNone0.41
Cancer44
Wong 2000Hong KongNormalNoneCervix freshNo controlsRFLP; DSRestrictionNo controlsNoneNo controls
SIL10
Cancer62
Baek 2000KoreaNormal103Cervix freshBloodASP; RFLPRestrictionConvenienceNone0.00
Cancer52
Kim 2000KoreaNormal181BloodBloodRFLPRestrictionVolunteersHPV16/18+0.41
Cancer181
Dokianakis 2000GreeceNormalf73Cervix archivalCervix archivalASPRestrictionConvenienceHPV16/18/33+0.02
SIL22
Cancer37
Madeleine 2000United KingdomNormal164BloodBloodASPRestrictionRisk-based (population)None0.92
Cancer111
van Duin 2000NetherlandsNormal86CervixgCervix archivalASPNot clearConvenienceHPV16+0.32
SIL89
Cancer71