Table 4.

Loss of p53 transcription and HPV 16 and/or 18 E6 expression in SCCHN patients with p53 codon 72 germ line heterozygosity (n = 55)

No loss of transcription (n = 29)Loss of transcription (n = 26)
HPV negative (n = 35)1817
    Pro coded 11
    Arg coded 6
HPV positive (n = 20)119
    Pro coded 5
    Arg coded 4
  • NOTE: Fisher's exact test was done to determine the influence of the presence of HPV E6 transcript on loss of p53 transcription (P = 0.23) and preferential allele-specific loss of p53 transcription (P = 0.69).