Table 3.

CBMN frequency (‰) in coke-oven and non–coke-oven workers by genotypes of phase I metabolic enzymes

GenotypesNon–coke-oven workers
Coke-oven workers
P*
nMean ± SDPnMean ± SDP
CYP1A1
    Ile/Ile374.7 ± 4.1Reference679.5 ± 7.2Reference<0.01
    Ile/Val222.6 ± 2.00.06619.5 ± 6.20.90<0.01
    Val/Val74.7 ± 3.70.72139.5 ± 5.40.670.02
    Ile/Val-Val/Val293.1 ± 2.60.17749.5 ± 6.00.81<0.01
CYP2E1PstI site
    c1/c1454.1 ± 3.6Reference929.7 ± 6.4Reference<0.01
    c1/c2213.7 ± 3.60.52479.4 ± 7.10.89<0.01
    c2/c2027.5 ± 3.50.98
    c1/c2-c2/c2213.7 ± 3.60.52499.3 ± 7.00.90<0.01
CYP2E1DraI site
    D/D384.2 ± 3.8Reference859.9 ± 6.5Reference<0.01
    D/C283.8 ± 3.40.56518.9 ± 6.90.21<0.01
    C/C0510.2 ± 7.00.92
    D/C-C/C283.8 ± 3.40.56569.0 ± 6.80.23<0.01
  • * Mann-Whitney U tests for the differences in CBMN frequencies between coke-oven workers and non–coke-oven workers by each genotype.

  • Multivariate analysis of covariance tests for differences in ln-transformed CBMN data between genotypes with adjustment for urinary 1-OHP, age, sex, and cigarettes per day in coke-oven workers and non–coke-oven workers separately.

  • Reference group for comparisons of ln-transformed CBMN data between genotypes.