Table 5

GSTM-1, NAT2-imputed phenotype, and cigarette smoking exposure and rectal cancer in men

GST present n (cases/controls)GST null n (cases/controls)GST present OR (95% CI)aGST null OR (95% CI)
Cigarette smoking status
 Never84/12388/1241.01.1 (0.7–1.6)
 Former106/11290/1281.5 (1.0–2.2)1.1 (0.7–1.6)
 Current (<5 yr)39/4463/431.3 (0.8–2.2)2.0 (1.2–3.3)
Pack-years smoked
 None86/12388/1251.01.1 (0.7–1.6)
 ≤2056/7853/881.1 (0.7–1.7)0.9 (0.6–1.4)
 >2088/77101/811.8 (1.2–2.8)1.9 (1.2–2.9)
Total long-term passive smoking (h/wk)
 None42/5939/541.01.0 (0.6–1.8)
 1–1095/126104/1391.0 (0.6–1.7)1.0 (0.6–1.6)
 >1082/8289/911.3 (0.8–2.1)1.3 (0.8–2.1)
Slow acetylatorRapid acetylatorSlow acetylatorRapid acetylator
Cigarette smoking status
 Never90/14374/1051.01.2 (0.8–1.8)
 Former112/12875/1051.5 (1.0–2.1)1.2 (0.8–1.8)
 Current (<5 yr)44/3553/452.0 (1.2–3.4)1.7 (1.0–2.8)
Pack-years smoked
 None91/14475/1051.01.2 (0.8–1.8)
 ≤2057/7945/771.2 (0.7–1.8)0.9 (0.6–1.5)
 >2098/8284/722.1 (1.4–3.2)1.9 (1.2–3.0)
Total long-term passive smoking (h/wk)
 None40/6538/481.01.3 (0.7–2.4)
 1–10100/14290/1191.1 (0.7–1.8)1.2 (0.7–1.9)
 >1098/8965/771.7 (1.0–2.8)1.3 (0.7–2.1)
  • a Adjusted for age, physical activity level, alcohol intake, usual number of cigarettes smoked/day (for passive smoking), and body size.