Table 4

Associations between GSTM-1 and NAT2-imputed phenotype and rectal cancer in men and women

MenWomen
Cases (n)Controls (n)OR (95% CI)aCases (n)Controls (n)OR (95% CI)
GSTM-1
 Present2302791.01671881.0
 Null2432951.0 (0.8–1.3)1612510.7 (0.6–1.0)
NAT2 (acetylator status)
 Slow2473061.01622141.0
 Rapid2042551.0 (0.8–1.3)1532150.9 (0.7–1.3)
GSTM-1/NAT2 combined
 Present/slow1301481.083871.0
 Present/rapid891250.8 (0.6–12)77970.8 (0.5–1.2)
 Null/slow1171560.9 (0.6–1.2)771230.6 (0.4–1.0)
 Null/rapid1151271.0 (0.7–1.4)761170.7 (0.5–1.1)
  • a Adjusted for age, physical activity level, alcohol intake, usual number of cigarettes smoked/day, and body size.