Table 3

Polymorphisms of ERPvuII and XbaI and breast cancer risk by age at diagnosis and menopausal status, Shanghai Breast Cancer Study, 1996–1998

Age ≤45Age >45
Case % (n = 471)Control % (n = 558)ORa95% CIFAR 95% CICase % (n = 598)Control % (n = 608)ORa95% CIFAR 95% CI
PvuII
 PP12.215.51.0(ref)b13.517.11.0(ref)
 Pp/pp87.884.51.4(1.0–2.0)86.582.91.3(1.0–1.8)
  Pp46.748.21.3(0.9–1.9)(1.1–1.5)49.745.51.4(1.0–1.9)(1.2–1.6)
  pp41.236.41.5(1.0–2.2)(1.2–1.9)36.937.41.3(0.9–1.8)(1.0–1.5)
 Trend testP = 0.036P = 0.406
XbaI
 XX4.14.51.0(ref)2.93.81.0(ref)
 Xx/xx95.995.51.1(0.6–2.0)97.196.21.4(0.7–2.6)
  Xx48.643.11.2(0.6–2.3)(1.0–1.5)44.844.01.4(0.7–2.6)(1.1–1.6)
  xx47.352.31.0(0.5–1.8)(0.8–1.2)52.452.21.4(0.7–2.6)(1.2–1.6)
Trend testP = 0.203P = 0.548
PremenopausalPostmenopausal
Case % (n = 715)Control % (n = 746)ORa95% CIFAR 95% CICase % (n = 349)Control % (n = 417)ORa95% CIFAR 95% CI
PvuII
 PP13.015.91.0(ref)12.917.01.0(ref)
 Pp/pp87.084.11.3(1.0–1.8)87.183.01.4(0.9–2.1)
  Pp47.647.61.3(0.9–1.8)(1.1–1.5)50.045.31.4(0.9–2.2)(1.2–1.8)
  pp39.436.51.4(1.0–1.9)(1.2–1.7)37.137.71.3(0.8–2.0)(1.0–1.7)
 Trend testP = 0.057P = 0.448
XbaI
 XX3.64.11.0(ref)2.94.11.0(ref)
 Xx/xx96.495.91.0(0.6–1.8)97.195.91.5(0.7–3.3)
  Xx47.844.91.1(0.6–1.9)(1.0–1.3)43.841.41.5(0.7–3.5)(1.2–1.9)
  xx48.551.01.0(0.6–1.7)(0.9–1.2)53.354.51.4(0.6–3.3)(1.2–1.8)
 Trend testP = 0.456P = 0.899
  • a Adjusted for age.

  • b ref, reference.