Analysis of PARP haplotype frequencies, ORs, and 95% CIs for lung cancer by selected variables
| No.a (%) | Adjusted OR (95% CI) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | |||||||||||||||
| 1-1-1b | 1-2-1 | 2-2-2 | 1-1-1 | 1-2-1 | 2-2-2 | 1-1-1 | 1-2-1 | 2-2-2 | ||||||||
| All subjects | 150 (21.3) | 242 (34.4) | 312 (44.3) | 137 (19.5) | 247 (35.1) | 320 (45.4) | 1.0 | 0.94 (0.70–1.27) | 0.92 (0.69–1.22)c | |||||||
| Age | ||||||||||||||||
| ≤61 | 68 (21.0) | 115 (35.5) | 141 (43.5) | 72 (20.5) | 125 (35.5) | 155 (44.0) | 1.0 | 1.04 (0.68–1.59) | 0.99 (0.66–1.49)d | |||||||
| >61 | 82 (21.6) | 127 (33.4) | 171 (45.0) | 65 (18.5) | 122 (34.7) | 165 (46.9) | 1.0 | 0.82 (0.54–1.26) | 0.82 (0.48–1.23)d | |||||||
| Sex | ||||||||||||||||
| Male | 119 (20.7) | 203 (35.2) | 254 (44.1) | 117 (20.3) | 196 (34.0) | 263 (45.7) | 1.0 | 1.07 (0.77–1.50) | 0.98 (0.72–1.35)e | |||||||
| Female | 31 (24.2) | 39 (30.5) | 58 (45.3) | 20 (15.6) | 51 (39.9) | 57 (44.5) | 1.0 | 0.56 (0.27–1.12) | 0.71 (0.35–1.41)e | |||||||
| Smoking status | ||||||||||||||||
| Never-smokerg | 25 (20.5) | 45 (36.9) | 52 (42.6) | 27 (16.1) | 64 (38.1) | 77 (45.8) | 1.0 | 0.70 (0.35–1.39) | 0.70 (0.36–1.37)f | |||||||
| <40 pysh | 49 (21.3) | 83 (36.1) | 98 (42.6) | 67 (20.7) | 112 (34.6) | 145 (44.7) | 1.0 | 1.05 (0.66–1.69) | 0.96 (0.61–1.52)f | |||||||
| ≥40 pys | 76 (21.6) | 114 (32.4) | 162 (46.0) | 43 (20.3) | 71 (33.5) | 98 (46.2) | 1.0 | 0.91 (0.57–1.47) | 0.94 (0.60–1.47)f | |||||||
| Histologic typei | ||||||||||||||||
| Squamous | 76 (22.6) | 111 (33.0) | 149 (44.3) | 1.0 | 0.85 (0.59–1.24) | 0.85 (0.59–1.21)c | ||||||||||
| Adeno | 47 (19.7) | 87 (36.6) | 104 (43.7) | 137 (19.5) | 247 (35.1) | 320 (45.4) | 1.0 | 1.03 (0.67–1.58) | 0.96 (0.64–1.44)c | |||||||
| Small | 23 (20.5) | 34 (30.4) | 55 (49.1) | 1.0 | 0.86 (0.49–1.54) | 1.07 (0.63–1.83)c | ||||||||||
a Each subject contributes two haplotypes to the analysis, thus, the total number of haplotypes in each column is twice the number of subjects.
b Wild allele is denoted by 1 and the polymorphic allele by 2. The order of the polymorphisms is as follows: codon 81, 284, and 762.
c Adjusted for age, sex, and pack-years.
d Adjusted for sex and pack-years.
e Adjusted for age and pack-years.
f Adjusted for age and sex.
g Current and former smokers.
h Pack-years.
i Nine large cell carcinomas were excluded.