Table 1

Analysis of PARP haplotype frequencies, ORs, and 95% CIs for lung cancer by selected variables

No.a (%)Adjusted OR (95% CI)
CasesControls
1-1-1b1-2-12-2-21-1-11-2-12-2-21-1-11-2-12-2-2
All subjects150 (21.3)242 (34.4)312 (44.3)137 (19.5)247 (35.1)320 (45.4)1.00.94 (0.70–1.27)0.92 (0.69–1.22)c
Age
 ≤6168 (21.0)115 (35.5)141 (43.5)72 (20.5)125 (35.5)155 (44.0)1.01.04 (0.68–1.59)0.99 (0.66–1.49)d
 >6182 (21.6)127 (33.4)171 (45.0)65 (18.5)122 (34.7)165 (46.9)1.00.82 (0.54–1.26)0.82 (0.48–1.23)d
Sex
 Male119 (20.7)203 (35.2)254 (44.1)117 (20.3)196 (34.0)263 (45.7)1.01.07 (0.77–1.50)0.98 (0.72–1.35)e
 Female31 (24.2)39 (30.5)58 (45.3)20 (15.6)51 (39.9)57 (44.5)1.00.56 (0.27–1.12)0.71 (0.35–1.41)e
Smoking status
 Never-smokerg25 (20.5)45 (36.9)52 (42.6)27 (16.1)64 (38.1)77 (45.8)1.00.70 (0.35–1.39)0.70 (0.36–1.37)f
 <40 pysh49 (21.3)83 (36.1)98 (42.6)67 (20.7)112 (34.6)145 (44.7)1.01.05 (0.66–1.69)0.96 (0.61–1.52)f
 ≥40 pys76 (21.6)114 (32.4)162 (46.0)43 (20.3)71 (33.5)98 (46.2)1.00.91 (0.57–1.47)0.94 (0.60–1.47)f
Histologic typei
 Squamous76 (22.6)111 (33.0)149 (44.3)1.00.85 (0.59–1.24)0.85 (0.59–1.21)c
 Adeno47 (19.7)87 (36.6)104 (43.7)137 (19.5)247 (35.1)320 (45.4)1.01.03 (0.67–1.58)0.96 (0.64–1.44)c
 Small23 (20.5)34 (30.4)55 (49.1)1.00.86 (0.49–1.54)1.07 (0.63–1.83)c
  • a Each subject contributes two haplotypes to the analysis, thus, the total number of haplotypes in each column is twice the number of subjects.

  • b Wild allele is denoted by 1 and the polymorphic allele by 2. The order of the polymorphisms is as follows: codon 81, 284, and 762.

  • c Adjusted for age, sex, and pack-years.

  • d Adjusted for sex and pack-years.

  • e Adjusted for age and pack-years.

  • f Adjusted for age and sex.

  • g Current and former smokers.

  • h Pack-years.

  • i Nine large cell carcinomas were excluded.