Table 3

Association of AR exon 1 CAGn polymorphism with breast cancer

Mean of alleles cut-offLong allele cut-off
No. ≤25No. >25Crude ORs (95% CI)Adjusteda ORs (95% CI)No. ≤25No. >25Crude ORs (95% CI)Adjusteda ORs (95% CI)
All women
 Cases242570.47 (0.28–0.8)0.47 (0.24–0.94)1831160.56 (0.39–0.81)0.43 (0.26–0.71)
 Controls2062316960
Age group
 <50
  Cases197420.56 (0.32–0.98)0.58 (0.27–1.23)146930.59 (0.40–0.89)0.45 (0.26–0.76)
  Controls1762114354
 50+
  Cases45150.2 (0.04–0.94)0.2 (0.03–1.15)37230.37 (0.13–1.04)0.35 (0.08–1.39)
  Controls302266
Menopause
 Premenopausal
  Cases181400.44 (0.23–0.82)0.39 (0.17–0.91)135860.6 (0.39–0.92)0.38 (0.21–0.68)
  Controls1561512447
 Postmenopausal
  Cases56160.36 (0.11–1.16)0.39 (0.08–1.75)45270.44 (0.18–1.06)0.43 (0.12–1.56)
  Controls394349
Family historyb
 Yes
  Cases32425110.67 (0.2–2.27)0.67 (0.14–3.08)
  Controls220175
 No
  Cases192490.38 (0.2–0.7)0.42 (0.2–0.89)146950.52 (0.34–0.8)0.38 (0.22–0.66)
  Controls1561512843
  • a Adjusted for age at menarche, age at first birth, age at last birth, oral contraceptive use, and smoking.

  • b Family history of breast or ovarian cancer, includes only subjects for whom this information was available.