Table 3

COMT genotype, sex hormones, and growth factors

Values are least square means (95% CI), and all of the models are adjusted for age and ethnicity. Results provided in italics have been further adjusted for BMI and WHR.a,b,ab

PremenopausalPostmenopausal
GenotypeFPGenotypeFP
*1/*1 n = 45c*1/*2 n = 98d*2/*2 n = 38e*1/*1 n = 46f*1/*2 n = 79g*2/*2 n = 46h
Sex hormones
 Total estradiol282.2 (209.9–365.3)237.8 (180.1–303.4)257.6 (185.5–341.5)0.880.4230.4 (24.6–38.4)32.2 (25.9–41.4)30.4 (24.6–38.4)0.380.68
  (pmol/liter) 291.0 (217.5–375.3) 241.5 (183.4–307.6) 242.7 (171.9–325.8) 1.11 0.33 30.7 (26.2–35.7) 33.9 (28.4–41.2) 32.9 (27.3–40.4) 0.58 0.56
 Free estradiol (%)2.02 (1.73–2.27)2.19 (197–2.40)2.21 (1.94–2.45)1.280.282.58 (2.38–2.76)2.37 (2.15–2.57)2.40 (2.16–2.62)1.900.15
2.14 (1.89–2.36) 2.23 (2.03–2.41) 2.13 (1.57–2.36) 0.62 0.54 2.57 (2.41–2.72) 2.40 (2.22–2.57) 2.53 (2.34–2.70) 2.16 0.12
 SHBG (nmol/liter)j62.3 (52.2–73.2)55.5 (47.1–64.6)54.5 (44.6–65.4)1.280.2839.6 (32.7–47.0)46.0 (37.9–54.9)46.8 (37.6–56.9)1.390.25
57.9 (48.8–67.8) 54.0 (46.3–62.4) 58.2 (48.5–68.8) 0.67 0.51 39.9 (34.0–46.4) 45.3 (38.2–53.0) 42.1 (34.6–50.4) 1.16 0.32
 Progesterone (nmol/liter)k36.8 (29.2–45.4)a25.0 (19.5–31.2)b20.8 (14.9–27.7)b9.170.00021.5 (1.2–1.8)1.6 (1.3–2.0)1.6 (1.3–2.0)0.440.65
34.5 (27.3–42.5) a 24.3 (19.1–30.2) b 21.4 (15.6–28.1) b 6.81 0.001 1.5 (1.2–1.8) 1.6 (1.3–2.0) 1.6 (1.3–2.0) 0.32 0.73
 FSH (IU/liter)l6.8 (5.2–9.0)a6.2 (4.9–7.9)ab4.8 (3.6–6.4)b2.980.0564.1 (55.9–73.5)61.0 (53.1–69.9)73.0 (61.2–87.0)2.690.07
6.4 (4.9–8.5) 6.0 (4.8–7.6) 4.9 (3.7–6.5) 1.61 0.20 63.8 (55.9–72.9) 61.2 (53.0–70.6) 69.5 (59.4–81.3) 1.56 0.21
Growth factors
 Prolactin (μg/liter)16.1 (13.0–20.0)14.3 (11.8–17.4)16.0 (12.6–20.2)0.970.388.0 (6.9–9.3)8.7 (7.4–10.1)8.3 (6.9–9.9)0.490.61
16.0 (12.9–19.8) 14.3 (11.8–17.3) 15.7 (12.5–19.7) 0.87 0.42 8.0 (6.9–9.2) 8.5 (7.3–9.9) 7.9 (6.7–9.4) 0.52 0.60
 GH (μg/liter)m1.41 (0.85–2.34)0.86 (0.56–1.33)0.96 (0.56–1.64)2.240.110.46 (0.30–0.72)0.46 (0.29–0.72)0.53 (0.32–0.88)0.220.80
1.29 (0.78–2.11) 0.82 (0.53–1.25) 1.06 (0.62–1.81) 2.18 0.12 0.45 (0.29–0.69) 0.44 (0.28–0.69) 0.47 (0.29–0.78) 0.06 0.94
 IGF-1 (μg/liter)n159.0 (147.5–170.9)a150.2 (140.5–160.1)a136.9 (125.8–148.4)b6.250.002129.0 (119.2–139.2)132.9 (122.5–143.7)134.5 (122.9–146.6)0.400.67
156.2 (145.4–167.3) a 148.6 (139.6–157.8) a 139.9 (129.2–151.1) b 3.51 0.03 129.0 (119.4–139.0) 134.3 (123.7–145.3) 132.2 (120.9–144.1) 0.44 0.65
 IGFBP-3 mg/litero2.53 (2.37–2.70)a2.66 (2.52–2.80)ab2.79 (2.61–2.97)b3.830.022.77 (2.62–2.92)2.85 (2.70–3.01)2.73 (2.56–2.91)1.270.28
2.58 (2.42–2.73) 2.68 (2.55–2.82) 2.73 (2.56–2.90) 1.70 0.19 2.76 (2.61–2.91) 2.82 (2.63–3.02) 2.72 (2.55–2.90) 0.80 0.45
  • a,b,ab Genotypes not sharing the same superscripts are significantly different, i.e., a and b are significantly different, but a and ab (or b and ab) are not significantly different (Bonferroni t test, P < 0.016).

  • c n = 44 for free estradiol, GH, IGF-1, and IGFBP-3.

  • d n = 97 for total estradiol, SHBG, and GH.

  • e n = 37 for total estradiol, SHBG, GH, IGF-1, and IGFBP-3.

  • f n = 43 for total estradiol and SHBG; n = 44 for free estradiol and FSH; n = 42 for GH, IGF-1, and IGFBP-3.

  • g n = 62 for total estradiol and SHBG; n = 69 for GH, IGF-1, and IGFBP-3.

  • h n = 40 for total estradiol and SHBG; n = 43 for GH, IGF-1, and IGFBP-3.

  • i Adjusted for SHBG.

  • j Adjusted for total estradiol levels.

  • k Models adjusted for FSH.

  • l Adjusted for progesterone levels in premenopausal women and for free estradiol values in postmenopausal women.

  • m Adjusted for IGF-1 and IGFBP-3.

  • n Adjusted for GH and IGFBP-3.

  • o Adjusted for GH and IGF-1.