COMT genotype and allele frequency distribution
n | COMT genotype distributiona | Allele frequency | |||||||
---|---|---|---|---|---|---|---|---|---|
*1/*1 | *1/*2 | *2/*2 | COMT*1 | COMT*2 | |||||
Premenopausal | |||||||||
All women | 181 | 45 | 98 | 38 | 0.52 | 0.48 | |||
Caucasian | 155 | 38 | 86 | 31 | 0.52 | 0.48 | |||
East Asian | 5 | 2 | 2 | 1 | 0.60 | 0.40 | |||
Jewish | 11 | 2 | 5 | 4 | 0.41 | 0.59 | |||
Other | 10 | 3 | 5 | 2 | 0.55 | 0.45 | |||
Postmenopausal | |||||||||
All women | 171 | 46 | 79 | 46 | 0.50 | 0.50 | |||
Caucasian | 141 | 28 | 71 | 42 | 0.45 | 0.55 | |||
East Asian | 9 | 7 | 2 | 0 | 0.89 | 0.11 | |||
Jewish | 6 | 2 | 2 | 2 | 0.50 | 0.50 | |||
Other | 15 | 9 | 4 | 2 | 0.73 | 0.27 |
a COMT*1/*1 is associated with the high-activity phenotype, *1/*2 with the intermediate-activity phenotype, and *2/*2 with the low-activity phenotype.