Table 2

COMT genotype and allele frequency distribution

nCOMT genotype distributionaAllele frequency
*1/*1*1/*2*2/*2COMT*1COMT*2
Premenopausal
 All women1814598380.520.48
 Caucasian1553886310.520.48
 East Asian52210.600.40
 Jewish112540.410.59
 Other103520.550.45
Postmenopausal
 All women1714679460.500.50
 Caucasian1412871420.450.55
 East Asian97200.890.11
 Jewish62220.500.50
 Other159420.730.27
  • a COMT*1/*1 is associated with the high-activity phenotype, *1/*2 with the intermediate-activity phenotype, and *2/*2 with the low-activity phenotype.