Table 2

COMT genotype and allele frequency distribution

	n	COMT genotype distribution^a					Allele frequency
	n			1/1	1/2	2/2	COMT*1	COMT*2
Premenopausal
All women	181	45	98	38	0.52	0.48
Caucasian	155	38	86	31	0.52	0.48
East Asian	5	2	2	1	0.60	0.40
Jewish	11	2	5	4	0.41	0.59
Other	10	3	5	2	0.55	0.45
Postmenopausal
All women	171	46	79	46	0.50	0.50
Caucasian	141	28	71	42	0.45	0.55
East Asian	9	7	2	0	0.89	0.11
Jewish	6	2	2	2	0.50	0.50
Other	15	9	4	2	0.73	0.27

^a COMT*1/*1 is associated with the high-activity phenotype, *1/*2 with the intermediate-activity phenotype, and *2/*2 with the low-activity phenotype.