Table 1

Selected characteristics of study subjects by menopausal status

Mean (SD)
CaucasianaEast AsianbJewishcOtherd
Pre n = 155Pre n = 5Pre n = 11Pre n = 10
Post n = 141Post n = 9Post n = 5Post n = 15
Premenopausal
 Risk factors
  Age, yr44.7 (4.7)47.4 (4.2)45.6 (3.0)45.5 (4.6)
  Height, cm163.8 (6.1)155.2 (6.3)161.7 (5.1)162.1 (10.4)
  Weight, kg68.25 (16.2)57.08 (5.9)60.32 (10.6)67.2 (15.3)
  BMI, kg/m225.4 (6.0)23.6 (1.2)23.0 (3.6)25.6 (5.5)
  Waist:Hip ratio0.75 (0.06)0.75 (0.04)0.73 (0.07)0.75 (0.06)
  Age at menarche, yr12.7 (1.4)12.6 (2.7)12.2 (0.6)13.8 (1.4)
  Age at first birth, yr28.1 (5.8)33.3 (6.7)29.5 (2.7)24.4 (7.9)
  No. of live births1.4 (1.2)1.2 (1.1)1.9 (1.4)1.8 (1.3)
  Mammographic density, %e28.0 (22.7)49.7 (15.5)37.0 (24.1)22.1 (17.5)
 Pituitary hormones and growth factors
  Prolactin, μg/liter16.3 (11.4)22.0 (15.6)12.8 (7.5)25.2 (20.9)
  GH, μg/liter1.7 (2.4)2.6 (4.5)2.5 (2.4)3.6 (6.2)
  IGF-1, μg/liter155.9 (35.8)149.0 (33.7)141 (35.0)143.6 (23.5)
  IGFBP-3, mg/liter2.7 (0.5)2.6 (0.3)2.7 (0.6)2.6 (0.5)
 Sex hormones
  Estradiol, pmol/liter321.2 (219.3)172.4 (115.8)239.2 (164.6)361.5 (165.6)
  Free estradiol, %2.2 (0.7)1.9 (0.6)1.9 (0.8)2.3 (0.6)
  SHBG, nmol/liter55.6 (26.1)63.6 (21.9)65.6 (27.8)49.1 (20.3)
  Progesterone, nmol/liter28.9 (22.7)30.0 (31.4)29.3 (21.6)31.6 (20.0)
  FSH, IU/liter9.3 (15.3)20.7 (25.9)10.3 (20.1)7.2 (8.5)
Postmenopausal
 Risk factors
  Age, yr56.1 (4.7)54.3 (3.3)53.7 (2.3)56.3 (4.1)
  Height, cm164.9 (6.6)157.1 (4.7)164.7 (4.4)162.2 (6.5)
  Weight, kg71.7 (16.9)56.4 (8.2)69.0 (16.6)65.3 (14.4)
  BMI, kg/m226.4 (6.1)23.0 (3.9)25.5 (6.2)24.8 (5.2)
  Waist:Hip ratio0.76 (0.08)0.77 (0.07)0.78 (0.10)0.79 (0.06)
  Age at menarche, yr13.1 (1.6)12.9 (1.5)12.7 (2.3)12.9 (2.2)
  Age at first birth, yr26.0 (5.2)33.2 (7.1)23.0 (3.3)29.7 (8.1)
  No. of live births1.7 (1.5)1.3 (1.4)2.2 (1.5)1.2 (1.2)
  Mammographic density,e %21.3 (19.4)50.7 (11.5)26.6 (24.3)30.5 (21.6)
 Pituitary hormones and growth factors
  Prolactin, μg/liter9.7 (5.6)8.8 (3.7)7.7 (3.1)10.4 (3.4)
  GH, μg/liter1.6 (2.6)1.5 (2.4)0.5 (0.4)0.7 (0.8)
  IGF-1, μg/liter128.2 (33.2)137.2 (38.1)133.5 (32.2)142.9 (41.8)
  IGFBP-3, mg/liter2.8 (0.5)2.8 (0.5)3.0 (0.5)2.8 (0.6)
 Sex hormones
  Estradiol, pmol/liter49.7 (98.8)46.4 (42.4)26.3 (10.2)46.9 (32.2)
  Free estradiol, %2.5 (0.6)2.2 (0.7)2.3 (0.6)2.5 (0.5)
  SHBG, nmol/liter42.5 (22.7)52.1 (26.1)48.3 (20.1)41.7 (16.8)
  Progesterone, nmol/liter1.7 (1.1)1.7 (0.7)1.6 (1.2)2.1 (0.9)
  FSH, IU/liter72.1 (30.7)71.1 (23.2)72.1 (11.1)71.7 (31.3)
  • a Premenopausal (Pre): n = 107 for age at first birth; n = 153 for GH; n = 154 for IGF-1, IGFBP-3, and free estradiol. Postmenopausal (Post): n = 104 for age at first birth; n = 127 for GH; n = 140 for IGF-1, IGFBP-3, free estradiol; n = 119 for total estradiol.

  • b Pre: n = 3 for age at first birth. Post: n = 6 for age at first birth; n = 7 for GH; n = 8 for total estradiol, free estradiol, and SHBG.

  • c Pre: n = 8 for age at first birth; n = 10 for GH. Post: n = 5 for age at first birth.

  • d Pre: n = 8 for age at first birth. Post: n = 10 for age at first birth.

  • e Proportion of breast area occupied by dense tissue.