Appendix

112 Screening strategies for detection of ≥CIN 3, sorted by decreasing Youden’s Index (Prevalence of ≥CIN 3 = 1.286%)

Screening combination% SensitivitySpecificityPositive predict. valueNegative predict. valueYouden’s index (with 95% CI)Total number screened by combination
Smear = HSIL+ or HPV+90.74%87.77%8.76%99.86%0.79 (0.73–0.84)8456
ThinPrep = HSIL+ or HPV+90.48%87.97%9.03%99.86%0.78 (0.73–0.84)8058
Cervigram = P2+ or HPV+89.72%88.07%8.82%99.85%0.78 (0.72–0.84)8428
Cervigram = P0+ or HPV+93.46%84.15%7.05%99.90%0.78 (0.73–0.82)8428
Smear = LSIL+ or HPV+91.67%85.79%7.70%99.87%0.77 (0.72–0.83)8456
Cervigram = P1+ or HPV+91.59%85.55%7.54%99.87%0.77 (0.72–0.82)8428
ThinPrep = ASCUS+ or Cervigram = P0+93.20%83.90%7.02%99.89%0.77 (0.72–0.82)7996
ThinPrep = LSIL+ or HPV+90.48%86.61%8.19%99.86%0.77 (0.71–0.83)8058
ThinPrep = ASCUS+ or Cervigram = P1+91.26%85.19%7.44%99.87%0.76 (0.71–0.82)7996
Smear = ASCUS+ or HPV+91.67%84.21%6.99%99.87%0.76 (0.71–0.81)8456
ThinPrep = LSIL+ or Cervigram = P0+84.47%91.26%11.20%99.78%0.76 (0.69–0.83)7996
Cervigram = P3 or HPV+86.92%88.21%8.66%99.81%0.75 (0.69–0.82)8428
ThinPrep = ASCUS+ or Cervigram = P2+87.38%87.53%8.38%99.81%0.75 (0.68–0.81)7996
ThinPrep = ASCUS+ or HPV+94.29%80.21%5.92%99.91%0.74 (0.70–0.79)8058
ThinPrep = LSIL+ or Cervigram = P1+81.55%92.69%12.71%99.74%0.74 (0.67–0.82)7996
Smear = HSIL+ or ThinPrep = ASCUS+86.54%87.58%8.37%99.80%0.74 (0.68–0.81)8036
ThinPrep = ASCUS+ or Cervigram = P386.41%87.69%8.39%99.80%0.74 (0.67–0.81)7996
HPV+85.32%88.22%8.58%99.78%0.74 (0.67–0.80)8519
ThinPrep = ASCUS+85.71%87.80%8.47%99.79%0.74 (0.67–0.80)8082
ThinPrep = ASCUS+ and HPV+77.14%95.84%19.66%99.69%0.73 (0.65–0.81)8058
Smear = LSIL+ or ThinPrep = ASCUS+86.54%85.92%7.46%99.79%0.72 (0.66–0.79)8036
Smear = HSIL+ or ThinPrep = LSIL+75.96%95.13%16.99%99.67%0.71 (0.63–0.79)8036
ThinPrep = LSIL+ or Cervigram = P2+75.73%95.31%17.41%99.67%0.71 (0.63–0.79)7996
Smear = ASCUS+ or ThinPrep = ASCUS+86.54%84.39%6.78%99.79%0.71 (0.64–0.78)8036
Cervigram = A+ or HPV+94.39%75.89%4.79%99.91%0.70 (0.66–0.75)8428
ThinPrep = HSIL+ or Cervigram = P0+75.73%94.24%14.63%99.67%0.70 (0.62–0.78)7996
ThinPrep = ASCUS+ or Cervigram = A+94.17%75.46%4.77%99.90%0.70 (0.65–0.74)7996
Smear = ASCUS+ or ThinPrep = LSIL+77.88%91.17%10.37%99.68%0.69 (0.61–0.77)8036
Smear = LSIL+ or ThinPrep = LSIL+75.96%92.93%12.34%99.66%0.69 (0.61–0.77)8036
ThinPrep = HSIL+ or Cervigram = P1+72.82%95.69%18.07%99.63%0.69 (0.60–0.77)7996
ThinPrep = LSIL+ or Cervigram = A+86.41%81.96%5.88%99.78%0.68 (0.62–0.75)7996
ThinPrep = LSIL+ or Cervigram = P372.82%95.48%17.36%99.63%0.68 (0.60–0.77)7996
ThinPrep = LSIL+71.43%95.55%17.44%99.61%0.67 (0.58–0.76)8082
Smear = ASCUS+ or ThinPrep = HSIL+73.08%93.24%12.42%99.62%0.66 (0.58–0.75)8036
Smear = LSIL+ or ThinPrep = HSIL+71.15%95.13%16.09%99.60%0.66 (0.58–0.75)8036
Smear = LSIL+ or Cervigram = P0+74.53%90.91%9.50%99.64%0.65 (0.57–0.74)8389