t1 Mean (CI)^{a} | t2 Mean (CI) | Difference t2-t1 (%) | t3 Mean (CI) | Difference t3-t1 (%) | P^{b} | |
---|---|---|---|---|---|---|
Age (years) | 57.6 (56.0–59.1) | 58.6 (57.1–60.2) | 1.0 (1.8) | 62.7 (61.1–64.2) | 5.1 (8.8) | NA |
BMI (kg/m^{2}) | 25.7 (24.6–26.9) | 25.6 (14.4–26.8) | −0.1 (0.4) | 26.3 (25.2–27.5) | 0.6 (2.3) | 0.035^{c} |
aMT6S^{d} (mg/l) | 11.00 (8.28–14.62) | 8.09 (6.08–10.75) | −2.9 (−26.5) | 7.04 (5.30–9.36) | −4.0 (−36.0) | 0.005 |
Creatinine^{d} (mg/l) | 818.6 (732.3–915.1) | 788.6 (705.4–881.5) | −30.0 (−3.7) | 727.0 (650.3–812.7) | −91.6 (−11.2) | 0.144 |
Adjusted aMT6S^{d} (ng/mg creatinine) | 13.44 (10.49–17.22) | 10.25 (8.00–13.14) | −3.2 (−23.7) | 9.69 (7.56–12.41) | −3.8 (−27.9) | 0.013 |
^{a} CI, confidence interval; t1, timepoint 1; t2, timepoint 2; t3, timepoint 3.
^{b} Test for heterogeneity using Greenhouse-Geisser’s ε as the correction factor for repeated measures.
^{c} If Box’s more conservative ε is used, this relationship becomes nonsignificant at the 5% level, P = 0.059.
^{d} Geometric means and 95% CI.