Table 3

Changes in insulin, glucose, insulin resistance, IGF-I, IGF-II, IGFBP-1, IGFBP-3, and IGF-I:IGFBP-3 molar ratioa

End pointBaselinePbWeek 15Mean changeDifference between groups in mean change (95% CI)P valuec
Insulin (pmol/liter)
 Exercise group (n = 25)60.2 (34.8)67.5 (51.9)+7.2 (26.0)
 Control group (n = 28)53.2 (36.3)0.38154.1 (37.3)+0.9 (18.8)+6.3 [−6.1 to 18.8]0.941
Glucose (mmol/liter)
 Exercise group (n = 25)5.9 (1.5)5.8 (1.7)−0.07 (1.0)
 Control group (n = 28)5.5 (0.8)0.2555.4 (0.9)−0.16 (0.5)+0.09 [−0.3 to 0.5]0.824
Insulin resistance index
 Exercise group (n = 25)2.3 (2.1)2.7 (3.0)+0.4 (1.4)
 Control group (n = 28)1.9 (1.7)0.4241.9 (1.9)0.0 (0.9)+0.4 [−0.3 to 1.0]0.247
IGF-I (ng/ml)
 Exercise group (n = 25)67.4 (29.1)62.5 (23.9)−4.9 (10.7)
 Control group (n = 28)70.0 (21.5)0.70572.6 (24.8)+2.5 (14.8)−7.4 [−14.6 to−0.2]0.045
IGF-II (ng/ml)
 Exercise group (n = 25)824.9 (155.5)805.0 (139.9)−19.9 (97.1)
 Control group (n = 28)714.5 (148.9)0.011735.3 (152.4)+20.9 (80.5)−40.7 [−89.7 to 8.3]0.101
IGFBP-1 (ng/ml)
 Exercise group (n = 25)47.5 (32.3)53.2 (30.4)+5.6 (13.4)
 Control group (n = 28)48.2 (29.8)0.93352.4 (34.2)+4.2 (21.2)+1.4 [−8.6 to 11.5]0.774
IGFBP-3 (ng/ml)
 Exercise group (n = 25)2160.8 (421.1)2264.2 (435.4)+103.4 (224.7)
 Control group (n = 28)2146.2 (438.2)0.9022069.1 (478.4)−77.1 (313.5)+180.5 [28.4 to 332.5]0.021
IGF-I:IGFBP-3 molar ratio
 Exercise group (n = 25)0.032 (.013).028 (0.012)−0.003 (0.006)
 Control group (n = 28)0.034 (.015)0.518.037 (0.015)+0.003 (0.01)−0.006 [−0.01 to−0.001]0.017
  • a Data are presented as the mean (SD).

  • b P for independent t tests comparing the exercise group and control group at baseline.

  • c P for independent t tests comparing changes between the exercise group and control group from baseline to week 15.