Table 1

Distribution of gene polymorphisms according to the different patient characteristics

PolymorphismAll subjects n = 109HWEPGenderbPEthnicityPAgebPSmokingbP
FaMBW<6060–6970SkNsk
XRCC3-(Thr241Met)
 Genotype
  Thr/Thr50 (46%)43%33 (57%)12 (32%)20 (69%)25 (37%)16 (55%)16 (57%)13 (32%)41 (43%)9 (69%)
  Thr/Met43 (39%)45%0.19c18 (31%)19 (50%)0.057 (24%)30 (44%)0.01311 (38%)8 (29%)18 (45%)0.1540 (42%)3 (23%)0.2
  Met/Met16 (15%)12%7 (12%)7 (18%)2 (69%)13 (19%)2 (7%)4 (14%)9 (23%)14 (15%)1 (8%)
  Thr/Met and Met/Met59 (54%)25 (43%)26 (68%)0.0219 (31%)43 (63%)0.00413 (45%)12 (43%)27 (68%)0.0754 (57%)4 (31%)0.14
NBS1-(Glu185Gln)
 Genotype
  Glu/Glu58 (53%)52%31 (53%)21 (55%)19 (69%)34 (50%)16 (55%)15 (54%)22 (55%)49 (52%)9 (69%)
  Glu/Gln41 (38%)40%0.49c23 (40%)12 (32%)0.59 (24%)26 (38%)0.2611 (38%)12 (43%)12 (30%)0.537 (39%)3 (23%)0.48
  Gln/Gln10 (9%)8%4 (7%)5 (13%)1 (69%)8 (12%)2 (7%)1 (4%)6 (15%).9 (9%)1 (8%)
  Glu/Gln and Gln/Gln51 (47%)27 (47%)17 (45%)1.0010 (31%)34 (50%)0.1913 (45%)13 (46%)18 (45%)0.9946 (48%)4 (31%)0.25
BRCA2-(Asn372His)
 Genotype
  Asn/Asn59 (54%)51%31 (53%)21 (55%)22 (76%)20 (37%)16 (55%)15 (54%)21 (52%)53 (56%)5 (38%)
  Asn/His38 (35%)40%0.14c21 (36%)13 (34%)0.987 (24%)27 (45%)0.00710 (35%)8 (29%)16 (40%)0.6933 (35%)5 (38%)0.27
  His/His12 (11%)8%6 (10%)4 (11%)0 (0%)11 (18%)3 (10%)5 (18%)3 (8%).9 (9%)3 (23%)
  Asn/His and His/His50 (46%)27 (47%)17 (45%)1.007 (24%)38 (63%)0.00713 (45%)13 (46%)19 (48%)0.9842 (44%)8 (62%)0.37
  • a F, females; M, males; B, blacks; W, whites; Sk, smokers; Nsk, nonsmokers.

  • b Calculated for those patients with available information.

  • c HWE among ethnicity: XRCC3 was P = 0.28 and P = 0.46 in B and W, respectively; NBS1 was P = 0.96 and P = 0.39 in B and W, respectively; BRCA2 was P = 0.46 and P = 0.26 in B and W, respectively.