Table 6

Distribution of bleomycin sensitivity (b/c) by XRCC1 genotype in lung cancer cases and controls

GenotypeCasesControls
nMeanSDPnMeanSDP
Exon 6
 Arg 1194 Arg, Arg 1194 Trp720.700.32Ref.730.560.24Ref.
 Trp 1194 Trp4520.810.420.0074510.650.350.005
Exon 10
 Arg 399 Arg2180.770.41Ref.2080.610.33Ref.
 Arg 399 Gln2400.810.400.3732370.640.330.417
 Gln 399 Gln660.840.480.288790.710.370.033
P(trend) = 0.225P(trend) = 0.040
Exons 6 and 10
 6-Arg/Arg, Arg/Trp
 10-Arg/Arg410.670.32Ref.430.600.24Ref.
 10-Arg/Gln4180.800.410.0134060.630.330.509
 6-Trp/Trp
 10-Gln/Gln650.840.480.025750.720.370.038
P(trend) = 0.049P(trend) = 0.032