Table 2

Genes expressed differentially in ascending and descending colon control all main cellular functions

CGAPa functional group of genesNo. of genes presented on 9k-arrayNo. of genes expressed differentially in colonb
TotalOverexpressed in ascending colonOverexpressed in descending colon
Cell proliferation2343910 (9.1×)29 (3.3×)
Cell cycle282597 (1.5×)52 (2.5×)
Cell death1382311 (1.9×)12 (3.1×)
Cell-cell signalling134135 (1.5×)8 (3.1×)
Cell adhesion122213 (1.8×)18 (3.1×)
Embryogenesis and morphogenesis6651 (3.1×)4 (3.3×)
Developmental processes126277 (3.1×)20 (8.1×)
Signal transduction5037424 (6.2×)50 (3.2×)
Angiogenesis93141 (6.7×)13 (3.1×)
DNA replication, damage, and adducts166333 (6.7×)30 (3.1×)
Response to external stimulus4967519 (2.9×)56 (5.4×)
Stress response285386 (2.9×)32 (5.4×)
Oncogenes177368 (2.6×)28 (3.3×)
Tumor suppressor genes101236 (1.8×)17 (3.3×)
Transcription factors2173110 (6.2×)21 (3.0×)
Receptors, ligands, and receptor signalling proteins172227 (6.7×)15 (3.1×)
EGF signalling21303 (1.8×)
TGFβ signalling10000
Wnt signalling1852 (1.6×)3 (1.6×)
Insulin signalling16303 (1.8×)
Ras signalling1642 (1.4×)2 (1.8×)
Integrin signalling2341 (1.3×)3 (1.8×)
EGF, TGFβ, Wnt, insulin, Ras, and integrin signalling (one set, no repeating genes)76155 (1.6×)10 (1.8×)
  • a CGAP, Cancer Genome Anatomy Project.

  • b At 0.001 level; maximal fold difference shown in parentheses.