Table 3

Risk of adenomatous colorectal polyps as a result of alcohol consumption and ADH3 genotypea

Alcohol consumption (drinks/week)b
<11–10≥10
All ADH3*1/*2, *2/*2 N (cases/controls)72/9699/105107/79
OR (95% CI)1 (REF)c0.97 (0.60–1.56)1.15 (0.70–1.90)
ADH3*1/*1 N (cases/controls)50/6740/4865/41
OR (95% CI)0.94 (0.53–1.64)0.99 (0.54–1.79)1.76 (1.00–3.11)
Women ADH3*1/*2, *2/*2 N (cases/controls)41/7751/6835/29
OR (95% CI)1 (REF)0.94 (0.51–1.74)1.38 (0.66–2.87)
ADH3*1/*1 N (cases/controls)35/5818/3116/12
OR (95% CI)0.90 (0.46–1.73)0.92 (0.42–2.05)2.61 (1.05–6.50)
Men ADH3*1/*2, *2/*2 N (cases/controls)31/1948/3772/50
OR (95% CI)1 (REF)1.03 (0.47–2.27)1.05 (0.50–2.20)
ADH3*1/*1 N (cases/controls)15/922/1749/29
OR (95% CI)1.31 (0.41–4.16)1.06 (0.42–2.69)1.50 (0.67–3.34)
  • a Adjusted for sex, age, and indication for endoscopy (complaints related, screening, other/unknown).

  • b One alcoholic consumption contains ∼10 g of ethanol.

  • c REF, reference group.