Table 4

ORs and 95% CIs for urinary phytoestrogens in relation to breast cancer risk, stratified by blood levels of steroid hormones and SHBG, the Shanghai Breast Cancer Study, 1996–1998

Steroid hormones (by median)Urinary excretion rate of isoflavonoids by tertilea,bUrinary excretion rate of lignans by tertilea,b
T1 (low)T2T3P for trendT1 (low)T2T3P for trend
E2 (pg/ml)≤5.731.001.04 (0.43–2.51)0.76 (0.26–2.18)0.651.000.68 (0.24–1.87)0.37 (0.12–1.17)0.08
>5.731.000.60 (0.21–1.74)0.22 (0.07–0.68)0.011.001.45 (0.51–4.09)0.61 (0.20–1.89)0.41
P for interaction, 0.18P for interaction, 0.40
E1 (pg/ml)≤17.851.000.67 (0.25–1.76)0.34 (0.11–1.04)0.071.000.68 (0.25–1.87)0.46 (0.17–1.30)0.13
>17.851.000.95 (0.37–2.46)0.47 (0.16–1.41)0.191.001.26 (0.50–3.15)0.49 (0.16–1.51)0.23
P for interaction, 0.07P for interaction, 0.58
E1-S (ng/ml)≤0.961.000.66 (0.23–1.85)0.20 (0.06–0.64)0.011.001.46 (0.50–4.29)0.62 (0.19–2.02)0.35
>0.961.001.05 (0.42–2.61)0.78 (0.27–2.27)0.671.000.75 (0.30–1.85)0.38 (0.11–1.35)0.15
P for interaction, 0.74P for interaction, 0.71
Testosterone (ng/ml)≤0.161.000.63 (0.20–1.99)0.47 (0.14–1.61)0.261.001.11 (0.33–3.76)0.58 (0.16–2.11)0.30
>0.161.001.05 (0.44–2.53)0.37 (0.13–1.07)0.091.000.98 (0.43–2.24)0.41 (0.15–1.17)0.12
P for interaction, 0.30P for interaction, 0.94
DHEA-S (ng/ml)≤589.81.000.63 (0.21–1.91)0.49 (0.16–1.49)0.241.000.82 (0.29–2.31)0.38 (0.11–1.32)0.14
>589.81.000.90 (0.36–2.22)0.38 (0.14–1.05)0.061.001.17 (0.43–3.15)0.53 (0.19–1.53)0.23
P for interaction, 0.74P for interaction, 0.91
SHBG (nmol/liter)≤81.41.000.52 (0.22–1.22)0.36 (0.13–0.97)0.031.001.35 (0.58–3.10)0.64 (0.23–1.82)0.60
>81.41.001.32 (0.48–3.68)0.67 (0.24–1.85)0.471.000.67 (0.20–2.27)0.33 (0.09–1.24)0.06
P for interaction, 0.46P for interaction, 0.40
  • a Cases and controls were categorized according to the tertile level of controls.

  • b Adjusted for age at first live birth, ever diagnosed with fibroadenoma, total meat intake, ever physically active, BMI, and blood SHBG level.