Table 2

Agents producing a very different effect on the tumor number in the small intestine and in the colon of Min mice (protection ratio below 0.4 or above 2.5 data from Table 1<$REFLINK> ) CategoryTreatmentnaTreatment effect: polyps in treated mice percent polyps in control miceProtection ratio: effect in small intestine versus effect in colonRef. Small intestineColon NSAIDSulindac11250.04 48 NSAIDSulindac17330.22 49 NSAIDPiroxicam3231500.15 43 NSAIDPiroxicam1351690.20 44 NSAID/2Celecoxib1482530.19 44 PPAR activ.BRL49,65311135250.22 78 PPAR activ.Troglitazone11042830.37 78 PPAR activ.Troglitazone11163000.39 79 inhib. INOSArginine deficient diet1673000.22 36 FiberHigh fiber chow1962710.35 23 FiberWheat bran2531430.37 23 FatFish oil K851331600.20 21 Other Citrobacter rodentium 1793500.23 58 OtherPEG 8000110430200.03 66 FiberFructo-oligosaccharide193332.8 25 OtherSelenium in broccoli171223.2 67 OtherUroguanylin257144.0 70 VitaminFolate/MinMsh2−14221004.2 81 PhytochemResveratrol1300100 76 • a See abbreviations and notes to Table 1<$REFLINK> .