Table 1

Effect of dietary agents on the tumor number in the small intestine and in the colon of Min mice, and other mutant mice

CategoryTreatment/mutationaDosebDurationcndSmall IntestineColonRef.
Adenoma numbereTreatment effectf %Adenoma numbergTreatment effectf %
TreatedControlTreatedControl
Bile acidChenodeoxycholic0.50%10 wk12533 77 0.60.4150 16
Bile acidUrsodeoxyc. + sulindac1500–4500 +75 ppm2318 15 17
Bile acidUrsodeoxyc. + sulindac500 +75 ppm1518 30 17
Bile acidUrsodeoxycholic acid500–1500 ppm21318 73 17
FatArachidonic acid1%7 wk15554101 18
FatCorn Oil10% vs. 3%150–300 day23223 137 3.81.8 212 19
FatDHA/Apc7163% female7 wk168219 31 20
FatDHA/Apc7163% male7 wk1278193144 20
FatFish oil K850.4% male17 wk/w1136108 33 1.61160 21
FatFish oil K851.25–2.5% male17 wk/w1280108740.7165 21
FatFish oil K850.4–1.25–2.5% female17 wk/w134073 55 0.30.838 21
FatHigh-fat low-fiber dietfat:cellul. 22:0 vs 7:5%5–6 wk13435981.41.878 22
FatLow soybean oil5% vs. 20, no fiber diet60 day11930 62 0.20.457 23
FatWestern diet/Apc1638Fat+, Ca−, vit. D−14–34 wk22.31233 24
FiberCellulose5–10% vs 0, in 20% fat60 day21430 45 0.40.4107 23
FiberFructo-oligosaccharide5.8%42 day14750930.72.1 33 25
FiberFructo-oligosaccharide5.8% in T-cell depleted42 day10.80.4 200 26
FiberGuar gum5–10% vs. 0, in 20% fat60 day21830 59 0.40.493 23
FiberHigh fiber rodent chowfiber:fat 18:6 vs. 0:20%60 day12829961.10.4 271 23
FiberInulin2.5%5–6 wk149351402.41.8133 22
FiberInulin10%9 wk168551231.30.6211 27
FiberOat bran10%5–6 wk147351331.81.8100 22
FiberResistant starch18.8%42 day150509932.1143 25
FiberRye bran10%5–6 wk12635 75 1.41.878 22
FiberRye bran10%/inulin diet5–6 wk1364091 28
FiberWheat bran10%5–6 wk13535992.11.8117 22
FiberWheat bran7.1%42 day14750941.52.171 25
FiberWheat bran5–10% vs. 0, in 20% fat60 day21630 53 0.60.4 143 23
FiberWheat bran, fat-/Apc716bran:fat 20:5 vs. 3:20%7 wk1135211 64 0.72 36 29
HAAIQ/Apc716300 ppm11 wk121325484 30
HAAMelQx/Apc716400 ppm11 wk122125487 30
HAAN-OH-PhiP/Apc71650 mg/kg × 5 inj.50 day/d2615717 335 30
HAAPhiP50 mg/kg× 8 inj.pups 3 wk123730 789 3.10.6 519 31
HAAPhiP25 mg/kg × 8 inj.pups 3 wk115730 524 0.90.6145 31
HAAPhiP50 mg/kg × 1 inj.7–11 wk216347 346 1.80.6 297 32
HAAPhiP10 mg/kg × 1 inj.7–11 wk28847 188 0.90.6157 32
HAAPhiP50 mg/kg × 4 inj.4 wk278721080.50.778 33
HAAPhiP/Apc16380.03% male and fem.182 day173 234 34
HAAPhiP/Apc716400 ppm8 wk1168147114 30
inhib. EGFEKB-569150 ppm60 day1320 13 35
inhib. EGFEKB-569 + sulindac150 +37.5 ppm60 day1120 4 35
inhib. EGFEKI-785300 ppm60 day11017 56 35
inhib. EGFEKI-785 + sulindac300 +150 ppm60 day1117 5 35
inhib. INOSAminoguanidine1500 ppm in water10 wk15073690.50.863 36
inhib. INOSArginine deficient dietNo arginine diet10 wk168102 67 0.60.2300 36
inhib. ODCDFMO2%69 day12145 46 3.23.592 37
inhib. ODCDFMO1%61 day12442 57 38
inhib. ODCDFMO + piroxicam1% +50 ppm61 day11142 27 38
inhib. desat.SC26196 n-6 desaturase100 mg/kg/day7 wk13454 63 18
NSAID4-ASA or 5-ASA500 ppm75 day210284122 39
NSAID5-ASA balzalazide250 mg/kg90 day1622 28 21 40
NSAID5-ASA balzalazide62–125 mg/kg90 day21122 49 19 40
NSAIDAspirine250–500 ppm7 wk21736 48 0.7165 41
NSAIDAspirine400 ppm370 day/d-211253474 42
NSAIDAspirine200 ppm130 day/d2113934115 42
NSAIDPiroxicam0.5 mg/mouse/day7 day1249 5 18
NSAIDPiroxicam25–50–100 ppm61 day32842 66 38
NSAIDPiroxicam50–100–200 ppm6 wk3417 23 0.90.6150 43
NSAIDPiroxicam50 ppm25 day/d551823 35 1.40.8169 44
NSAIDPiroxicam50 ppm50 day/d301522 23 0.61.540 44
NSAIDPiroxicam200 ppm90–180 day3253 4 45
NSAIDPiroxicam200 ppm6–14 day3453 7 45
NSAIDPiroxicam200 or 220 ppm75 day21268 18 39
NSAIDPiroxicam200 ppm2–4 day2345364 45
NSAIDPiroxicam/Apc13090.05%10 wk11631 52 1.52.6 56 46
NSAIDR-flurbiprofen10 mg/kg/day or/2d gav.21 day2823 35 47
NSAIDSulindac160 ppm11.5 wk1012 1 0.10.425 48
NSAIDSulindac320 ppm80 day1341 7 0.30.833 49
NSAIDSulindac0.6 mg/mouse/day7 day12246 48 18
NSAIDSulindac160 ppm10 wk1917 51 34.567 50
NSAIDSulindac75–150 ppm2418 22 17
NSAIDSulindac160 ppm75 day11384 16 39
NSAIDSulindac300 ppm10 wk1497268 51
NSAIDSulindac150 ppm60 day1417 26 35
NSAIDSulindac/Apc716150 ppm8 wk1125201 62 52
NSAIDSulindac/Apc71612 mg/kg/day8 wk1356424840.91.850 53
NSAIDSulindac/MinMsh2−13 mg/kg/day4 wk1294354 83 1413108 54
NSAIDSulindac/MinMsh13 mg/kg/day22 wk133447454.8104 54
NSAIDSulindac sulfone50 mg/kg/day gav.42 day1192577 47
NSAID/2Celecoxib1500 ppm25 day/d5511123 48 20.8253 44
NSAID/2Celecoxib500–1500 ppm50 day/d302622 29 0.61.537 44
NSAID/2Celecoxib150–500 ppm25–50 day31723 73 0.71.165 44
NSAID/2JTE-523100 ppm8 wk184123 68 55
NSAID/2MF-tricyclic/Apc7163.5–14 mg/kg/day8 wk2187424 44 0.31.8 19 53
NSAID/2MF-tricyclic/MinMsh13 mg/kg/day4–22 wk292200 46 5.79 63 54
NSAID/2ONO-AE2-227300 ppm7 wk14261 69 0.20.540 56
NSAID/2Rofecoxib/Apc71625–75 ppm8 wk2111201 55 52
OtherBeef meat24%5–6 wk153351503.21.8178 22
OtherBovine lactoferrin0.2% or 2%8 wk144548211.283 57
Other Citrobacter rodentium 10E8 cfu, one gav.152 day179792.80.8 350 58
OtherCopper6 vs 1 ppm13 wk12247 46 0.3127 59
OtherDSS4% in water4 or 8 day224.21.7 1421 60
OtherExercise1.2 km/1 h/day7 wk13337892.43.275 61
OtherFood restriction20% restriction7 wk15155931.12.348 62
OtherGerm-free statusgerm-free85 day12832880.91.466 63
OtherMethionine0.7%4 wk12526960.90.5180 64
OtherPEG 335010%10 wk12242 53 2.63.281 65
OtherPEG 8000/MinMsh2+ or −5% in male and fem.60 day113121040.70 3020 66
OtherSelenium in broccoli2.1 ppm Se10 wk14867 71 0.41.9 22 67
OtherSelenium p-XSC10–20 ppm80 day22441 58 1.22.8 43 68
OtherSphingomyelin-ceramides0.1%8 wk33156 56 0.71.4 50 69
OtherUroguanylin26 μg/mouse/day11 wk22748 57 0.10.7 14 70
OtherVegetables and fruits mix.20% mix in 9% fat diet110 day/d-2021417822.31.5152 71
OtherVegetables and fruits mix.22% mix in 20% fat diet110 day/d-2022817 162 2.31.5152 71
PhytochemAcarbose/Apc1309400 ppm10 wk12931932.22.684 46
PhytochemBB protease inhibitor0.1–0.5%92 day/d-22711 63 0.40.6 67 72
PhytochemCaffeic CAPE0.15%75 day11233 37 73
PhytochemCatechin (+)0.1–1%75 day2726 27 0.10.617 74
PhytochemCurcumin0.2%10 wk1131494 75
PhytochemCurcumin0.1%75 day11233 36 73
PhytochemLignan HMR200 ppm/inulin diet5–6 wk12740 67 1.71.3131 28
PhytochemResveratrol100 ppm in water7 wk1930 30 04 0 76
PhytochemRutin-quercetin2%75 day2283385 73
PhytochemSoy isoflavones475 ppm vs. 16 ppm11 wk2313199 77
PhytochemTea extract + sulindac0.1% water +300 ppm10 wk13272 44 51
PhytochemTea extract (green)0.1% in water10 wk1567278 51
PPAR activ.BRL49,65320 mg/kg/day8 wk131271133.20.6 525 78
PPAR activ.Troglitazone150 mg/kg/day8 wk123221041.70.6 283 78
PPAR activ.Troglitazone0.2%5 wk1786711631 300 79
Vitamin BFolate8–20 ppm13 wk/w321924803.74.680 80
Vitamin BFolate2–8–20 ppm26 wk/w3323181263.12.6120 80
Vitamin BFolate/MinMsh2−8 ppm8 wk/w31111299 37 0.61.735 81
Vitamin BFolate/MinMsh2−8 ppm5 wk/w6129570 422 2.42.4100 81
Vitamin BFolate + choline2 ppm + 3% vs. 0+ 1.470 day/d2133329114 82
Vitamin D1a,25 (OH)2-D33 × 0.01 μg/wk10 wk1181710844.589 50
Vitamin DRo 26-91143 × 5 μg/wk10 wk117171024.74.5104 50
  • a Mutation given when different from the Apc850 mutation (classical Min mouse).

  • b Dose: ppm, part per million; % of diet; mg/kg of body weight; inj., injection; gav., gavage.

  • c Treatment start: /w1: from 1 week after birth; /d-20: from 20 days before birth.

  • d Number of similar studies from a single article which were pooled before reporting mean value.

  • e Number of adenomas in the small intestine of treated and of control mice (some studies report total number of intestinal adenomas, and do not give colonic values).

  • f Treatment effect, calculated as: 100 × (number of adenomas in treated mice)/(number in control mice). A percentage smaller than 100 denotes a protective effect. Boldface: significant effect.

  • g Number of adenomas in the colon of treated and of control mice.