Table 1

ORs for developing NPC for genetic polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, and NAT2 after adjustment for age, sex, ethnicity, education level, and exposure to cigarette smoking

Genetic polymorphismsCasesControlsOR (95% CI)
No. (%)No. (%)
CYP1A1
 m1/m174 (43.0)83 (38.1)1.0
 m1/m275 (43.6)96 (44.0)1.2 (0.7–1.8)
 m2/m223 (13.4)39 (17.9)1.4 (0.8–2.6)
GSTM1
 Non-null141 (44.9)168 (49.9)1.0
 Null173 (55.1)169 (50.1)0.8 (0.6–1.1)
GSTT1
 Non-null156 (49.4)162 (48.2)1.0
 Null160 (50.6)174 (51.8)1.0 (0.8–1.4)
GSTP1
 1a/1a183 (69.3)232 (71.8)1.0
 1a/1b75 (28.4)86 (26.6)1.0 (0.6–1.4)
 1b/1b6 (2.3)5 (1.6)0.7 (0.2–2.3)
NAT2
 Slow39 (14.0)54 (16.6)1.0
 Fast240 (86.0)271 (83.4)0.8 (0.5–1.2)