Table 1

Association between self-reported history of polio vaccination and risk of glioma, meningioma, and acoustic neuroma among patients from hospitals in Boston, Phoenix, and Pittsburgh, United States, 1994–1998

ConditionControlsa (N = 799)GliomaMeningiomaAcoustic neuroma
Casesa,b (N = 489)ORc95% CIdCasesa (N = 197)ORc95% CICasesa (N = 96)ORe95% CI
Polio vaccination
 Nof102651.00f331.00f81.00f
 Yes6143611.080.75–1.561531.100.68–1.82791.460.63–3.38
Route
 Oral2011441.330.89–2.00591.220.70–2.12321.550.66–4.00
 Injection2761210.770.51–1.16570.900.52–1.57301.370.56–3.58
 Both56431.380.81–2.36141.030.47–2.2140.620.15–2.24
Year of vaccination
 <1954154941.050.68–1.63491.100.62–1.96281.950.80–5.15
 1954–19622231331.080.71–1.66530.950.53–1.70331.300.54–3.41
 1963+164951.260.78–2.05321.580.79–3.1870.690.20–2.33
Year of birth
 <19401841321.150.77–1.72621.190.71–2.02311.940.84–4.94
 1941–19623211720.930.57–1.53820.940.49–1.84420.750.28–2.16
 1963+109571.020.55–1.8890.760.26–2.1661.020.24–4.36
  • a Numbers may not add up to column totals because of missing data.

  • b The high-grade glioma cases (N = 354) include 241 patients diagnosed with glioblastoma (236) or gliosarcoma (5), 70 patients diagnosed with anaplastic astrocytoma, 25 patients diagnosed with anaplastic oligodendroglioma or mixed glioma, 9 patients diagnosed with embryonal tumors, 3 patients diagnosed with anaplastic ependymomas, and 6 others. The low-grade gliomas (N = 135) include 46 oligodendrogliomas, 34 astrocytomas, 17 gangliogliomas, 14 mixed gliomas, 7 ependymomas, 4 neurocytomas, and 13 others.

  • c ORs were adjusted for matching factors.

  • d 95% CIs were computed using profile likelihood function.

  • e ORs were adjusted for matching factors and education as indicated in Ref. 8 .

  • f Referent group.