Table 1

Association between HRAS1 variable number of tandem repeat alleles and genotypes and breast cancer in the Nurses’ Health Study, 1989–1996

AlleleRepeat numbersCase allelesControl allelesOdds ratio (95% confidence interval)Multivariate odds ratio (95% confidence interval)
All women
 Common a1308429181.00 (Ref)a1.00 (Ref)b
 Common a2461591711.03 (0.82–1.31)1.10 (0.86–1.41)
 Common a367–691501681.00 (0.79–1.27)1.07 (0.83–1.37)
 Common a483–851301480.99 (0.76–1.28)1.05 (0.80–1.37)
 Rare < a126–2918240.77 (0.41–1.42)0.73 (0.38–1.41)
 Rare a1–a231–45871250.80 (0.60–1.07)0.88 (0.64–1.19)
 Rare a2–a347–6628301.13 (0.66–1.93)1.26 (0.72–2.20)
 Rare a3–a470–821773.60 (1.38–9.38)3.06 (1.14–8.21)
 Rare > a486–96350.47 (0.09–2.45)0.37 (0.06–2.19)
All women
 Common allele128114051.00 (Ref)a1.00 (Ref)b
 Rare allele1531910.92 (0.73–1.15)0.95 (0.75–1.21)
Premenopausal womenc
 Common allele1761801.00 (Ref)d1.00 (Ref)e
 Rare allele18200.86 (0.43–1.70)0.86 (0.41–1.81)
Postmenopausal womenc
 Common allele100411171.00 (Ref)d1.00 (Ref)f
 Rare allele1241550.91 (0.71–1.17)0.88 (0.68–1.14)
GenotypeCasesControlsOdds ratio (95% confidence interval)Multivariate odds ratio (95% confidence interval)
All women
 Common/common5726181.00 (Ref)a1.00 (Ref)b
 Common/rare1371690.91 (0.70–1.18)0.97 (0.73–1.27)
 Rare/rare8110.84 (0.33–2.12)0.83 (0.32–2.14)
Premenopausal womenc
 Common/common79811.00 (Ref)d1.00 (Ref)e
 Common/rare or rare/rare18190.91 (0.43–1.91)0.94 (0.41–2.15)
Postmenopausal womenc
 Common/common4484901.00 (Ref)d1.00 (Ref)f
 Common/rare or rare/rare1161460.89 (0.67–1.17)0.86 (0.65–1.15)
  • a Conditional logistic regression estimates adjusted for matching variables: age; menopausal status; postmenopausal hormone use; date of blood draw; time of blood draw; and fasting status at blood draw.

  • b Conditional logistic regression estimates adjusted for matching variables and age at menarche (<12, 12, 13, >13 years), age at menopause (≤45, 46–50, 51–60 years), first degree family history of breast cancer (yes/no), history of benign breast disease (yes/no), weight gain since age 18 (<5, ≥5 to <20, ≥20 kg), body mass index at age 18 (continuous), age at first birth/parity (nulliparous, one to four children age at first birth ≤24 years, one to four children age at first birth >24 years, five or more children age at first birth ≤24 years, five or more children age at first birth >24 years), and duration of postmenopausal hormone use (premenopausal, never, past user <5 years duration, past user ≥5 years duration, current user <5 years duration, current user ≥5 years duration).

  • c Premenopausal and postmenopausal women do not add to the total number of women because women with uncertain menopausal status at diagnosis were excluded.

  • d Unconditional logistic regression adjusted for the matching variables.

  • e Unconditional logistic regression adjusted for the matching variables and body mass index at age 18 years, weight gain since age 18 years, age at menarche, history of benign breast disease, first degree family history, and age at first birth/parity.

  • f Unconditional logistic regression adjusted for the matching factors, the factors above, age at menopause, and duration of postmenopausal hormone use.