Table 1

Estimates of the penetrance for BRCA1 (F̂1; 10 ), BRCA2 (F̂2; 9 ), and for BRCAu, and noncarriers in Model I (F̂u,I and F̂0,I) and in Model II (F̂u,II and F̂0,II)

AgeBRCA1BRCA2BRCAu, Model IBRCAu, Model II
F1F2u,I0,Iu,II0,II
400.190.120.0820.00160.140.0011
500.510.280.170.0120.250.0106
600.540.480.280.0270.420.025
700.850.840.380.0480.570.048
μ53.958.556.366.367.772.0
ς16.513.817.214.925.716.5
c0.961.000.480.081.000.10
  • The formula for the penetrance function for each of these genes is given by the product of c and Φ (age − μ)/ς, where Φ denotes the normal cumulative distribution.