Table 5

Joint effects (ORa) of XRCC1, XRCC3, XPD polymorphisms and occupational PAHs and aromatic amines exposure

GenotypePAHsAromatic amines
NeverEverNeverEver
XRCC1 codon 399 Arg/Arg 57/59b36/3385/898/3
Ref.1.13 (0.62–2.06)Ref.2.74 (0.70–10.70)
Arg/Gln, Gln/Gln 67/8241/4098/11310/9
0.84 (0.51–1.36)1.05 (0.60–1.86)0.89 (0.60–1.34)1.19 (0.46–3.08)
XRCC3 codon 241Thr/Thr56/4833/2379/6810/3
Ref.1.24 (0.64–2.39)Ref.2.92 (0.77–11.07)
Thr/Met, Met/Met 68/9344/50104/1348/9
0.63 (0.38–1.03)0.76 (0.43–1.33)0.67 (0.44–1.01)0.78 (0.28–2.13)
XPD codon 751Lys/Lys49/5530/2570/749/6
Ref.1.37 (0.71–2.64)Ref.1.58 (0.53–4.68)
Lys/Gln, Gln/Gln 75/8647/48113/1289/6
0.98 (0.60–1.61)1.10 (0.63–1.92)0.93 (0.61–1.40)1.63 (0.55–4.84)
  • a Adjusted for age in unconditional logistic regression.

  • b Number of cases/number of controls.