Table 4

Joint effect of XRCC1, XRCC3, and XPD polymorphisms and tobacco smoking

GenotypeSmokingCasesControlsORa (95% CI)Test for interaction P
XRCC1 codon 399
Arg/ArgNo727Ref.
Arg/ArgYes86655.10 (2.09–12.45)
Arg/Gln, Gln/GlnNo10261.47 (0.49–4.46)
Arg/Gln, Gln/GlnYes98963.89 (1.62–9.36)0.28
XRCC3 codon 241
Thr/ThrNo716Ref.
Thr/ThrYes82553.36 (1.30–8.71)
Thr/Met, Met/MetNo10370.61 (0.20–1.89)
Thr/Met, Met/MetYes1021062.18 (0.86–5.52)0.92
XPD codon 751
Lys/LysNo414Ref.
Lys/LysYes75664.03 (1.26–12.88)
Lys/Gln, Gln/GlnNo13391.19 (0.33–4.27)
Lys/Gln, Gln/GlnYes109954.05 (1.29–12.72)0.80
  • a Adjusted for age in unconditional logistic regression.