Table 3

XRCC1, XRCC3, XPD polymorphisms and bladder cancer risk stratified by smoking

GenotypeNonsmokersLight smokersHeavy smokers
CasesControlsORa (95% CI)CasesControlsORa (95% CI)CasesControlsORa (95% CI)
XRCC1 codon 399
Arg/Arg727Ref.2434Ref.6231Ref.
Arg/Gln6211.11 (0.32–3.82)23380.94 (0.44–2.00)58390.74 (0.41–1.36)
Gln/Gln453.11 (0.66–14.80)871.76 (0.55–5.60)9120.38 (0.14–1.02)
Arg/Gln, Gln/Gln10261.50 (0.49–4.54)31451.07 (0.53–2.19)67510.66 (0.37–1.17)
XRCC3 codon 241
Thr/Thr716Ref.1627Ref.6628Ref.
Thr/Met7310.52 (0.16–1.77)32441.20 (0.56–2.61)48410.50 (0.27–0.93)
Met/Met361.14 (0.22–5.90)781.49 (0.45–4.92)15130.46 (0.19–1.10)
Thr/Met, Met/Met10370.63 (0.20–1.95)39521.25 (0.59–2.64)63540.49 (0.28–0.88)
XPD codon 751
Lys/Lys414Ref.1635Ref.5931Ref.
Lys/Gln12291.41 (0.38–5.21)26292.09 (0.93–4.69)49400.58 (0.32–1.09)
Gln/Gln1100.34 (0.03–3.54)13151.80 (0.69–4.71)21110.99 (0.42–2.35)
Lys/Gln, Gln/Gln13391.13 (0.31–4.10)39441.99 (0.95–4.16)70510.67 (0.38–1.20)
  • a Adjusted for age in unconditional logistic regression.