Table 3

Genotype frequencies, adjusted RRs and 95% CIs for esophageal, gastric cardia, and combined esophageal and gastric cardia cancers and MTHFR C677T and MTRR A66G by alcohol intake, Linxian Nutrition Intervention Trials

Cancer and genotypeAlcohol use during past 12 monthsaP-interaction
NoYes
MTHFR C677T
 Esophageal
  CC or CT (n)65/21016/75
   RRb1.00 (reference)1.00 (reference)
  TT (n)36/10012/31
   RRb1.28 (0.78–2.11)1.92 (0.80–4.58)0.32
 Gastric cardia
  CC or CT (n)45/2068/76
   RRb1.00 (reference)1.00 (reference)
  TT (n)24/10213/29
   RRb1.19 (0.68–2.09)5.32 (1.66–17.02)0.03
 Esophageal/gastric cardia
  CC or CT (n)110/20124/73
   RRb1.00 (reference)1.00 (reference)
  TT (n)60/9725/27
   RRb1.25 (0.83–1.89)2.82 (1.37–5.79)0.04
MTRR A66G
 Esophageal
  AA (n)35/15415/45
   RRb1.00 (reference)1.00 (reference)
  AG (n)53/13110/51
   RRb2.06 (1.23–3.45)0.63 (0.25–1.58)
  GG (n)13/253/10
   RRb2.39 (1.08–5.30)1.22 (0.26–5.66)0.01
    P-trendc0.0030.69
 Gastric cardia
  AA (n)31/14812/45
   RRb1.00 (reference)1.00 (reference)
  AG (n)29/1338/50
   RRb1.21 (0.69–2.14)0.81 (0.27–2.44)
  GG (n)9/271/10
   RRb1.49 (0.62–3.59)0.90 (0.09–9.31)0.49
    P-trendc0.320.75
 Esophageal/gastric cardia
  AA (n)66/14627/140
   RRb1.00 (reference)1.00 (reference)
  AG (n)82/12918/50
   RRb1.66 (1.09–2.52)0.69 (0.33–1.43)
  GG (n)22/234/10
   RRb1.94 (1.01–3.74)1.20 (0.33–4.52)0.08
    P-trendc0.0080.63
  • a Determined in 1985.

  • b Adjusted for age, sex, trial, BMI, and smoking.

  • c Trends across three genotypes estimated using score tests from a continuous variable based on the number of variant alleles in each genotype.