Genotype frequencies, adjusted RRs and 95% CIs for esophageal, gastric cardia, and combined esophageal and gastric cardia cancers and MTHFR C677T and MTRR A66G by alcohol intake, Linxian Nutrition Intervention Trials
| Cancer and genotype | Alcohol use during past 12 monthsa | P-interaction | ||
|---|---|---|---|---|
| No | Yes | |||
| MTHFR C677T | ||||
| Esophageal | ||||
| CC or CT (n) | 65/210 | 16/75 | ||
| RRb | 1.00 (reference) | 1.00 (reference) | ||
| TT (n) | 36/100 | 12/31 | ||
| RRb | 1.28 (0.78–2.11) | 1.92 (0.80–4.58) | 0.32 | |
| Gastric cardia | ||||
| CC or CT (n) | 45/206 | 8/76 | ||
| RRb | 1.00 (reference) | 1.00 (reference) | ||
| TT (n) | 24/102 | 13/29 | ||
| RRb | 1.19 (0.68–2.09) | 5.32 (1.66–17.02) | 0.03 | |
| Esophageal/gastric cardia | ||||
| CC or CT (n) | 110/201 | 24/73 | ||
| RRb | 1.00 (reference) | 1.00 (reference) | ||
| TT (n) | 60/97 | 25/27 | ||
| RRb | 1.25 (0.83–1.89) | 2.82 (1.37–5.79) | 0.04 | |
| MTRR A66G | ||||
| Esophageal | ||||
| AA (n) | 35/154 | 15/45 | ||
| RRb | 1.00 (reference) | 1.00 (reference) | ||
| AG (n) | 53/131 | 10/51 | ||
| RRb | 2.06 (1.23–3.45) | 0.63 (0.25–1.58) | ||
| GG (n) | 13/25 | 3/10 | ||
| RRb | 2.39 (1.08–5.30) | 1.22 (0.26–5.66) | 0.01 | |
| P-trendc | 0.003 | 0.69 | ||
| Gastric cardia | ||||
| AA (n) | 31/148 | 12/45 | ||
| RRb | 1.00 (reference) | 1.00 (reference) | ||
| AG (n) | 29/133 | 8/50 | ||
| RRb | 1.21 (0.69–2.14) | 0.81 (0.27–2.44) | ||
| GG (n) | 9/27 | 1/10 | ||
| RRb | 1.49 (0.62–3.59) | 0.90 (0.09–9.31) | 0.49 | |
| P-trendc | 0.32 | 0.75 | ||
| Esophageal/gastric cardia | ||||
| AA (n) | 66/146 | 27/140 | ||
| RRb | 1.00 (reference) | 1.00 (reference) | ||
| AG (n) | 82/129 | 18/50 | ||
| RRb | 1.66 (1.09–2.52) | 0.69 (0.33–1.43) | ||
| GG (n) | 22/23 | 4/10 | ||
| RRb | 1.94 (1.01–3.74) | 1.20 (0.33–4.52) | 0.08 | |
| P-trendc | 0.008 | 0.63 | ||
a Determined in 1985.
b Adjusted for age, sex, trial, BMI, and smoking.
c Trends across three genotypes estimated using score tests from a continuous variable based on the number of variant alleles in each genotype.