Genistein dose level (mg/kg) | Daidzein dose level (mg/kg) | No. of patients | T_{max}^{a}^{b} (h) | C_{max} (μm) | AUC_{0-∞} (μm·h) | Apparent T_{1/2}^{c} (h) | CL/F (liters/h) | V_{Z}/F (liters) | MRT (h) |
---|---|---|---|---|---|---|---|---|---|
2 | 0.2 | 4 | 4.5 (3–8) | 1.53 (0.99) | 30.0 (21.3) | 7.3 (10.0) | 1.18 (1.64) | 15.6 (12.9) | 29.12 (28.47) |
4 | 0.4 | 3 | 8 (8–24) | 29.6 (42.9) | 1296 (1710)^{d} | 33.8 (14.4)^{d} | 0.23 (0.30)^{d} | 15.3 (20.9)^{d} | 42.63 (2.18)^{d} |
8 | 0.8 | 4 | 6.25 (4.5–8) | 1.23 (0.51) | 39.3 (27.9) | 8.00 (10.1) | 2.5 (1.92) | 58.0 (37.3) | 56.55 (53.88) |
Totals | 11 | 8.0 (3–24) | 9.05 (10.7) | 1.52 (1.73) | 32.5 (32.4) | 42.79 (37.49) |
a T_{max}, time of maximal plasma concentration; C_{max}, maximal plasma concentration; AUC_{0-∞}, area under the concentration-time curve extrapolated to infinity; CL/F, apparent clearance; T_{1/2}, apparent terminal half-life of elimination; V_{Z}/F, apparent volume of distribution during the terminal elimination phase.
b Median and range.
c Harmonic means and pseudostandard deviations.
d Unable to estimate terminal elimination in one patient, n = 2.