Genistein dose level (mg/kg) | Daidzein dose level (mg/kg) | No. of patients | T_{max}^{a}^{b} (h) | C_{max} (μm) | AUC_{0-∞} (μm·h) | Apparent T_{1/2}^{c} (h) | CL/F (liters/h) | V_{Z}/F (liters) | MRT (h) |
---|---|---|---|---|---|---|---|---|---|
2 | 0.98 | 4 | 4.5 (1–48) | 2.36 (1.85) | 27.7 (22.0) | 6.69 (2.32)^{d} | 25.6 (30.8)^{d} | 206.0 (198.6)^{d} | 10.37 (1.18) |
4 | 1.95 | 3 | 4.5 (4.5–6) | 9.88 (6.54) | 167.9 (118.3) | 9.20 (16.70) | 7.42 (5.79) | 100.7 (21.4) | 21.98 (14.4) |
8 | 3.91 | 3 | 8 (6–24) | 10.11 (4.23) | 481.3 (636.1) | 7.48 (4.86) | 8.16 (6.16) | 85.4 (9.0) | 32.9 (36.5) |
Totals | 10 | 6.0 (1–48) | 7.65 (4.58) | 13.7 (18.3) | 134.1 (114.2) | 21.7 (21.9) |
a T_{max}, time of maximal plasma concentration; C_{max}, maximal plasma concentration; AUC_{0-∞}, area under the concentration-time curve extrapolated to infinity; CL/F, apparent clearance; T_{1/2}, apparent terminal half-life of elimination; V_{Z}/F, apparent volume of distribution during the terminal elimination phase.
b Median and range.
c Harmonic means and pseudostandard deviations.
d Unable to estimate terminal elimination in one patient, n = 3.