Table 4

Risk of prostate cancer in relation to hormone concentrations in serum, adjusted for age and race

HormoneQuartilesaP for trend
1 (low)234 (high)
A (nmol/L)b1.00.89 (0.56–1.41)1.07 (0.68–1.69)1.20 (0.76–1.89)0.32
[74, 75]c[64, 74][78, 75][84, 74]
0.85–2.04d2.04–2.592.59–3.323.32–7.48
SHBG (nmol/L)1.00.82 (0.52–1.31)0.98 (0.62–1.54)1.04 (0.66–1.64)0.69
[77, 75][64, 75][78, 76][81, 74]
8–2121–2727–3636–81
Total T (nmol/L)1.00.84 (0.53–1.32)0.87 (0.56–1.37)0.82 (0.52–1.29)0.43
[85, 75][71, 74][75, 75][69, 74]
4.0–11.311.3–14.214.2–17.817.8–39.4
Free Te (pmol/L)1.01.07 (0.69–1.67)0.8 (0.51–1.26)0.72 (0.45–1.14)0.09
[84, 75][89, 74][68, 75][59, 74]
89–274274–344344–412412–723
% Free T1.01.21 (0.78–1.87)0.83 (0.52–1.30)0.74 (0.46–1.19)0.10
[80, 75][98, 76][67, 77][55, 70]
1.41–2.162.16–2.392.39–2.632.63–3.31
Total T/SHBG1.00.72 (0.46–1.13)0.93 (0.60–1.43)0.52 (0.32–0.83)0.03
[96, 75][68, 74][87, 74][49, 75]
0.10–0.430.43–0.510.51–0.640.64–1.11
3α-diol G (nmol/L)1.00.90 (0.56–1.45)1.48 (0.95–2.33)1.27 (0.80–2.00)0.10
[67, 77][58, 74][94, 74][81, 75]
1.83–8.658.65–12.2712.27–18.0618.06–81.96
Total E2 (nmol/L)1.00.96 (0.62–1.50)0.90 (0.57–1.40)0.71 (0.42–1.13)0.15
[84, 75][80, 74][76, 75][60, 74]
0.13–0.170.17–0.190.19–0.220.22–0.36
Free E2e (pmol/L)1.00.65 (0.41–1.01)0.71 (0.46–1.10)0.52 (0.33–0.82)0.01
[104, 74][67, 74][75, 75][54, 74]
2.38–4.524.52–5.155.15–5.905.90–9.64
% Free E21.01.05 (0.68–1.62)1.07 (0.69–1.67)0.65 (0.4–1.05)0.14
[81, 76][87, 78][82, 72][50, 72]
1.81–2.472.47–2.662.66–2.882.88–3.50
DHEAS (nmol/L)1.00.99 (0.62–1.58)1.25 (0.79–1.99)1.38 (0.86–2.21)0.11
[68, 75][65, 75][81, 75][86, 75]
87–12491249–19491949–30793079–7965
  • a Odds ratio (95% confidence interval) by control quartiles of serum levels.

  • b A, androstenedione; T, testosterone; 3α-diol G, 3α-androstanediol glucuronide; DHEAS, dehydroepi androsterone sulfate; E2, estradiol; SHBG, sex hormone binding globulin.

  • c [Case N, control N].

  • d Range of analyte values within each control quartile.

  • e Calculated value—see text.