Table 3

Number of DNA repair variant alleles and breast cancer risk

Total no. of variant allelesaControls (n = 266)Cases (n = 246)Adjusted OR (95% CI)b
087 (33%)67 (27%)Referent
1114 (43%)95 (39%)1.04 (0.67–1.61)
257 (21%)66 (27%)1.38 (0.83–2.29)
3+8 (3%)18 (7%)2.60 (1.03–6.59)c
  • a XRCC1 Arg194Trp, XRCC3 Thr241Met, and ERCC4/XPF Arg415Glngenotypes were included in the model.

  • b OR adjusted for age, FH, age at menarche, age at first live birth, and BMI using logistic regression.

  • c P = 0.04, test for linear trend.