Table 2

Dietary factors and MSIa in sporadic colon carcinomas: case-control and case-case comparisons

ORs (95% CIs)b
T1T2T3PtrendContinuousc
Vegetables (g/day)≤166166–223>223/106
 No. MSI-H/MSS/controls20/70/8712/45/878/29/8540/144/259
 All cases vs. controls1.00.6 (0.4–1.0)0.4 (0.2–0.6)<0.010.6 (0.5–0.8)
 MSI-H vs. controls1.00.5 (0.2–1.2)0.4 (0.1–0.9)0.020.6 (0.4–0.9)
 MSS vs. controls1.00.7 (0.4–1.1)0.4 (0.2–0.7)<0.010.6 (0.5–0.8)
 MSI-H vs. MSS1.00.9 (0.4–2.0)0.8 (0.3–2.2)0.670.9 (0.6–1.5)
Fruit (g/day)≤142142–269≥269/164
 No. MSI-H/MSS/controls15/51/8715/49/8510/44/8740/144/259
 All cases vs. controls1.00.9 (0.6–1.5)0.7 (0.5–1.2)0.220.9 (0.7–1.0)
 MSI-H vs. controls1.01.0 (0.4–2.3)0.6 (0.2–1.4)0.210.8 (0.6–1.2)
 MSS vs. controls1.00.9 (0.6–1.5)0.8 (0.5–1.3)0.400.9 (0.7–1.1)
 MSI-H vs. MSS1.01.1 (0.5–2.6)0.7 (0.3–1.8)0.470.9 (0.7–1.4)
Red meat (g/day)<5858–87≥87/43
 No. MSI-H/MSS/controls16/33/8511/56/8713/55/8740/144/259
 All cases vs. controls1.01.3 (0.8–2.1)1.2 (0.7–1.9)0.601.1 (0.8–1.4)
 MSI-H vs. controls1.00.6 (0.3–1.5)0.5 (0.2–1.2)0.110.6 (0.4–1.0)
 MSS vs. controls1.01.6 (1.0–2.8)1.5 (0.9–2.6)0.191.2 (0.9–1.6)
 MSI-H vs. MSS1.00.3 (0.1–0.8)0.3 (0.1–0.9)0.030.5 (0.3–0.9)
Fish (g/day)<77–19>19/20
 No. MSI-H/MSS/controls15/43/829/41/9116/60/8640/144/259
 All cases vs. controls1.00.8 (0.5–1.3)1.1 (0.7–1.7)0.621.1 (0.9–1.2)
 MSI-H vs. controls1.00.6 (0.2–1.5)0.9 (0.4–1.9)0.841.0 (0.7–1.3)
 MSS vs. controls1.00.8 (0.5–1.4)1.2 (0.7–2.0)0.431.1 (0.9–1.3)
 MSI-H vs. MSS1.00.6 (0.2–1.6)0.6 (0.3–1.4)0.270.9 (0.7–1.1)
Dairy products (g/day)≤117117–305>305/287
 No. MSI-H/MSS/controls12/45/8712/48/8616/51/8640/144/259
 All cases vs. controls1.01.0 (0.6–1.6)1.0 (0.6–1.6)0.871.1 (0.9–1.4)
 MSI-H vs. controls1.00.9 (0.4–2.3)1.1 (0.5–2.7)0.701.2 (0.8–1.7)
 MSS vs. controls1.01.0 (0.6–1.6)0.9 (0.5–1.6)0.771.1 (0.9–1.4)
 MSI-H vs. MSS1.01.0 (0.4–2.5)1.3 (0.5–3.2)0.541.1 (0.8–1.5)
Alcohold (g/day)<3.83.8–12.9>12.9/18.4
 No. MSI-H/MSS/controls12/57/8610/31/8718/56/8640/144/259
 All cases vs. controls1.00.8 (0.5–1.3)1.2 (0.7–1.9)0.301.1 (1.0–1.4)
 MSI-H vs. controls1.01.2 (0.5–3.2)1.9 (0.8–4.7)0.131.2 (0.9–1.7)
 MSS vs. controls1.00.7 (0.4–1.2)1.0 (0.6–1.8)0.491.1 (0.9–1.4)
 MSI-H vs. MSS1.01.7 (0.6–4.6)1.7 (0.7–4.1)0.361.1 (0.9–1.4)
Dietary fiberd (g/day)<2525–31>31/10.3
 No. MSI-H/MSS/controls17/69/8611/32/8712/43/8640/144/259
 All cases vs. controls1.00.5 (0.3–0.8)0.6 (0.4–1.0)0.030.7 (0.6–1.0)
 MSI-H vs. controls1.00.8 (0.3–1.8)0.7 (0.3–1.7)0.480.8 (0.5–1.3)
 MSS vs. controls1.00.5 (0.3–0.8)0.6 (0.3–1.0)0.030.7 (0.5–0.9)
 MSI-H vs. MSS1.01.6 (0.6–3.9)1.2 (0.5–2.9)0.711.1 (0.7–1.8)
Calciumd (mg/day)≤10621062–1358>1358/458.3
 No. MSI-H/MSS/controls12/48/8713/35/8615/61/8640/144/259
 All cases vs. controls1.00.9 (0.6–1.5)1.3 (0.8–2.1)0.221.0 (0.8–1.3)
 MSI-H vs. controls1.01.4 (0.6–3.4)1.5 (0.6–3.5)0.421.1 (0.7–1.5)
 MSS vs. controls1.00.8 (0.5–1.4)1.3 (0.8–2.2)0.241.0 (0.8–1.3)
 MSI-H vs. MSS1.01.8 (0.7–4.5)1.1 (0.4–2.6)0.991.0 (0.7–1.5)
Vitamin Cd (mg/day)≤8989–133>133/68.5
 No. MSI-H/MSS/controls17/62/8718/49/865/33/8640/144/259
 All cases vs. controls1.00.9 (0.5–1.4)0.5 (0.3–0.8)<0.010.7 (0.5–0.9)
 MSI-H vs. controls1.01.2 (0.5–2.5)0.3 (0.1–0.8)0.030.5 (0.3–0.8)
 MSS vs. controls1.00.8 (0.5–1.3)0.5 (0.3–0.9)0.020.7 (0.6–1.0)
 MSI-H vs. MSS1.01.3 (0.6–2.9)0.5 (0.2–1.6)0.380.7 (0.4–1.2)
  • a The subset MSI-L/MSS is, for brevity, called MSS in this table.

  • b Adjusted for age, sex, body mass index, and total energy intake. Alcohol is additionally adjusted for cigarette smoking. Trend was assessed using the median values of the tertiles as continuous variables.

  • c Per interquartile range (Q3 to Q1).

  • d Adjusted for total energy intake by regression analysis, for women and men separately.