Dietary factors and MSIa in sporadic colon carcinomas: case-control and case-case comparisons
| ORs (95% CIs)b | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| T1 | T2 | T3 | Ptrend | Continuousc | |||||
| Vegetables (g/day) | ≤166 | 166–223 | >223 | /106 | |||||
| No. MSI-H/MSS/controls | 20/70/87 | 12/45/87 | 8/29/85 | 40/144/259 | |||||
| All cases vs. controls | 1.0 | 0.6 (0.4–1.0) | 0.4 (0.2–0.6) | <0.01 | 0.6 (0.5–0.8) | ||||
| MSI-H vs. controls | 1.0 | 0.5 (0.2–1.2) | 0.4 (0.1–0.9) | 0.02 | 0.6 (0.4–0.9) | ||||
| MSS vs. controls | 1.0 | 0.7 (0.4–1.1) | 0.4 (0.2–0.7) | <0.01 | 0.6 (0.5–0.8) | ||||
| MSI-H vs. MSS | 1.0 | 0.9 (0.4–2.0) | 0.8 (0.3–2.2) | 0.67 | 0.9 (0.6–1.5) | ||||
| Fruit (g/day) | ≤142 | 142–269 | ≥269 | /164 | |||||
| No. MSI-H/MSS/controls | 15/51/87 | 15/49/85 | 10/44/87 | 40/144/259 | |||||
| All cases vs. controls | 1.0 | 0.9 (0.6–1.5) | 0.7 (0.5–1.2) | 0.22 | 0.9 (0.7–1.0) | ||||
| MSI-H vs. controls | 1.0 | 1.0 (0.4–2.3) | 0.6 (0.2–1.4) | 0.21 | 0.8 (0.6–1.2) | ||||
| MSS vs. controls | 1.0 | 0.9 (0.6–1.5) | 0.8 (0.5–1.3) | 0.40 | 0.9 (0.7–1.1) | ||||
| MSI-H vs. MSS | 1.0 | 1.1 (0.5–2.6) | 0.7 (0.3–1.8) | 0.47 | 0.9 (0.7–1.4) | ||||
| Red meat (g/day) | <58 | 58–87 | ≥87 | /43 | |||||
| No. MSI-H/MSS/controls | 16/33/85 | 11/56/87 | 13/55/87 | 40/144/259 | |||||
| All cases vs. controls | 1.0 | 1.3 (0.8–2.1) | 1.2 (0.7–1.9) | 0.60 | 1.1 (0.8–1.4) | ||||
| MSI-H vs. controls | 1.0 | 0.6 (0.3–1.5) | 0.5 (0.2–1.2) | 0.11 | 0.6 (0.4–1.0) | ||||
| MSS vs. controls | 1.0 | 1.6 (1.0–2.8) | 1.5 (0.9–2.6) | 0.19 | 1.2 (0.9–1.6) | ||||
| MSI-H vs. MSS | 1.0 | 0.3 (0.1–0.8) | 0.3 (0.1–0.9) | 0.03 | 0.5 (0.3–0.9) | ||||
| Fish (g/day) | <7 | 7–19 | >19 | /20 | |||||
| No. MSI-H/MSS/controls | 15/43/82 | 9/41/91 | 16/60/86 | 40/144/259 | |||||
| All cases vs. controls | 1.0 | 0.8 (0.5–1.3) | 1.1 (0.7–1.7) | 0.62 | 1.1 (0.9–1.2) | ||||
| MSI-H vs. controls | 1.0 | 0.6 (0.2–1.5) | 0.9 (0.4–1.9) | 0.84 | 1.0 (0.7–1.3) | ||||
| MSS vs. controls | 1.0 | 0.8 (0.5–1.4) | 1.2 (0.7–2.0) | 0.43 | 1.1 (0.9–1.3) | ||||
| MSI-H vs. MSS | 1.0 | 0.6 (0.2–1.6) | 0.6 (0.3–1.4) | 0.27 | 0.9 (0.7–1.1) | ||||
| Dairy products (g/day) | ≤117 | 117–305 | >305 | /287 | |||||
| No. MSI-H/MSS/controls | 12/45/87 | 12/48/86 | 16/51/86 | 40/144/259 | |||||
| All cases vs. controls | 1.0 | 1.0 (0.6–1.6) | 1.0 (0.6–1.6) | 0.87 | 1.1 (0.9–1.4) | ||||
| MSI-H vs. controls | 1.0 | 0.9 (0.4–2.3) | 1.1 (0.5–2.7) | 0.70 | 1.2 (0.8–1.7) | ||||
| MSS vs. controls | 1.0 | 1.0 (0.6–1.6) | 0.9 (0.5–1.6) | 0.77 | 1.1 (0.9–1.4) | ||||
| MSI-H vs. MSS | 1.0 | 1.0 (0.4–2.5) | 1.3 (0.5–3.2) | 0.54 | 1.1 (0.8–1.5) | ||||
| Alcohold (g/day) | <3.8 | 3.8–12.9 | >12.9 | /18.4 | |||||
| No. MSI-H/MSS/controls | 12/57/86 | 10/31/87 | 18/56/86 | 40/144/259 | |||||
| All cases vs. controls | 1.0 | 0.8 (0.5–1.3) | 1.2 (0.7–1.9) | 0.30 | 1.1 (1.0–1.4) | ||||
| MSI-H vs. controls | 1.0 | 1.2 (0.5–3.2) | 1.9 (0.8–4.7) | 0.13 | 1.2 (0.9–1.7) | ||||
| MSS vs. controls | 1.0 | 0.7 (0.4–1.2) | 1.0 (0.6–1.8) | 0.49 | 1.1 (0.9–1.4) | ||||
| MSI-H vs. MSS | 1.0 | 1.7 (0.6–4.6) | 1.7 (0.7–4.1) | 0.36 | 1.1 (0.9–1.4) | ||||
| Dietary fiberd (g/day) | <25 | 25–31 | >31 | /10.3 | |||||
| No. MSI-H/MSS/controls | 17/69/86 | 11/32/87 | 12/43/86 | 40/144/259 | |||||
| All cases vs. controls | 1.0 | 0.5 (0.3–0.8) | 0.6 (0.4–1.0) | 0.03 | 0.7 (0.6–1.0) | ||||
| MSI-H vs. controls | 1.0 | 0.8 (0.3–1.8) | 0.7 (0.3–1.7) | 0.48 | 0.8 (0.5–1.3) | ||||
| MSS vs. controls | 1.0 | 0.5 (0.3–0.8) | 0.6 (0.3–1.0) | 0.03 | 0.7 (0.5–0.9) | ||||
| MSI-H vs. MSS | 1.0 | 1.6 (0.6–3.9) | 1.2 (0.5–2.9) | 0.71 | 1.1 (0.7–1.8) | ||||
| Calciumd (mg/day) | ≤1062 | 1062–1358 | >1358 | /458.3 | |||||
| No. MSI-H/MSS/controls | 12/48/87 | 13/35/86 | 15/61/86 | 40/144/259 | |||||
| All cases vs. controls | 1.0 | 0.9 (0.6–1.5) | 1.3 (0.8–2.1) | 0.22 | 1.0 (0.8–1.3) | ||||
| MSI-H vs. controls | 1.0 | 1.4 (0.6–3.4) | 1.5 (0.6–3.5) | 0.42 | 1.1 (0.7–1.5) | ||||
| MSS vs. controls | 1.0 | 0.8 (0.5–1.4) | 1.3 (0.8–2.2) | 0.24 | 1.0 (0.8–1.3) | ||||
| MSI-H vs. MSS | 1.0 | 1.8 (0.7–4.5) | 1.1 (0.4–2.6) | 0.99 | 1.0 (0.7–1.5) | ||||
| Vitamin Cd (mg/day) | ≤89 | 89–133 | >133 | /68.5 | |||||
| No. MSI-H/MSS/controls | 17/62/87 | 18/49/86 | 5/33/86 | 40/144/259 | |||||
| All cases vs. controls | 1.0 | 0.9 (0.5–1.4) | 0.5 (0.3–0.8) | <0.01 | 0.7 (0.5–0.9) | ||||
| MSI-H vs. controls | 1.0 | 1.2 (0.5–2.5) | 0.3 (0.1–0.8) | 0.03 | 0.5 (0.3–0.8) | ||||
| MSS vs. controls | 1.0 | 0.8 (0.5–1.3) | 0.5 (0.3–0.9) | 0.02 | 0.7 (0.6–1.0) | ||||
| MSI-H vs. MSS | 1.0 | 1.3 (0.6–2.9) | 0.5 (0.2–1.6) | 0.38 | 0.7 (0.4–1.2) | ||||
a The subset MSI-L/MSS is, for brevity, called MSS in this table.
b Adjusted for age, sex, body mass index, and total energy intake. Alcohol is additionally adjusted for cigarette smoking. Trend was assessed using the median values of the tertiles as continuous variables.
c Per interquartile range (Q3 to Q1).
d Adjusted for total energy intake by regression analysis, for women and men separately.